Title |
Of LAP, CUPS, and DRibbles – Unconventional Use of Autophagy Proteins for MHC Restricted Antigen Presentation
|
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Published in |
Frontiers in immunology, April 2015
|
DOI | 10.3389/fimmu.2015.00200 |
Pubmed ID | |
Authors |
Christian Münz |
Abstract |
Macroautophagy delivers cytoplasmic constituents for lysosomal degradation. Because MHC class II molecules are loaded with lysosomal products for CD4(+) T-cell stimulation, macroautophagy supports intracellular antigen processing onto MHC class II molecules. The molecular machinery of macroautophagy, however, does not only support this autophagic antigen processing, but seems to also modify extracellular antigen uptake for MHC class II presentation, antigen exocytosis, and packaging for improved cross-presentation onto MHC class I molecules. The different membrane trafficking pathways with LC3-associated phagocytosis, compartment for unconventional protein secretion, and DRibbles as well as the role that autophagic proteins play in them will be discussed in this review. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 52 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 19% |
Researcher | 9 | 17% |
Student > Master | 8 | 15% |
Student > Doctoral Student | 4 | 8% |
Student > Postgraduate | 3 | 6% |
Other | 7 | 13% |
Unknown | 12 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 26% |
Biochemistry, Genetics and Molecular Biology | 11 | 21% |
Immunology and Microbiology | 6 | 11% |
Medicine and Dentistry | 3 | 6% |
Environmental Science | 1 | 2% |
Other | 3 | 6% |
Unknown | 15 | 28% |