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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Anatomy of a Discovery: M1 and M2 Macrophages
|
|---|---|
| Published in |
Frontiers in immunology, May 2015
|
| DOI | 10.3389/fimmu.2015.00212 |
| Pubmed ID | |
| Authors |
Charles Dudley Mills |
| Abstract |
M1 and M2 macrophage-type responses kill or repair in vivo. The unique ability of macrophages to make these polar opposite type of responses provides primary host protection and maintains tissue homeostasis throughout the animal kingdom. In humans and other higher animals, M1 and M2-type macrophage responses also initiate and direct T cells/adaptive immunity to provide additional protection such as Th1 (cytotoxic) or Th2 (antibody-mediated) type responses. Hence, macrophages were renamed M1 and M2 to indicate the central role of macrophages/innate immunity in immune systems. These findings indicate that the long held notion that adaptive immunity controls innate immunity was backward: a sea change in understanding how immune responses occur. The clinical impact of M1/kill and M2/repair responses is immense playing pivotal roles in curing (or causing) many diseases including infections, cancer, autoimmunity, and atherosclerosis. How M1/M2 came to be is an interesting story that, like life, involved Direction, Determination, Discouragement, and Discovery. |
X Demographics
The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 7% |
| United States | 1 | 7% |
| Argentina | 1 | 7% |
| United Kingdom | 1 | 7% |
| Unknown | 10 | 71% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 93% |
| Scientists | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 558 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Sweden | 1 | <1% |
| Spain | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 553 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 106 | 19% |
| Student > Master | 77 | 14% |
| Student > Bachelor | 68 | 12% |
| Researcher | 64 | 11% |
| Student > Doctoral Student | 31 | 6% |
| Other | 76 | 14% |
| Unknown | 136 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 107 | 19% |
| Agricultural and Biological Sciences | 86 | 15% |
| Medicine and Dentistry | 78 | 14% |
| Immunology and Microbiology | 62 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 3% |
| Other | 61 | 11% |
| Unknown | 149 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2022.
All research outputs
#3,026,269
of 25,374,647 outputs
Outputs from Frontiers in immunology
#3,151
of 31,520 outputs
Outputs of similar age
#37,315
of 279,211 outputs
Outputs of similar age from Frontiers in immunology
#22
of 176 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,520 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,211 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 176 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.