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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Mechanisms of Autoantibody Production in Systemic Lupus Erythematosus
|
|---|---|
| Published in |
Frontiers in immunology, May 2015
|
| DOI | 10.3389/fimmu.2015.00228 |
| Pubmed ID | |
| Authors |
Shuhong Han, Haoyang Zhuang, Stepan Shumyak, Lijun Yang, Westley H. Reeves |
| Abstract |
Autoantibodies against a panoply of self-antigens are seen in systemic lupus erythematosus, but only a few (anti-Sm/RNP, anti-Ro/La, anti-dsDNA) are common. The common lupus autoantigens are nucleic acid complexes and levels of autoantibodies can be extraordinarily high. We explore why that is the case. Lupus is associated with impaired central or peripheral B-cell tolerance and increased circulating autoreactive B cells. However, terminal differentiation is necessary for autoantibody production. Nucleic acid components of the major lupus autoantigens are immunostimulatory ligands for toll-like receptor (TLR)7 or TLR9 that promote plasma cell differentiation. We show that the levels of autoantibodies against the U1A protein (part of a ribonucleoprotein) are markedly higher than autoantibodies against other antigens, including dsDNA and the non-nucleic acid-associated autoantigens insulin and thyroglobulin. In addition to driving autoantibody production, TLR7 engagement is likely to contribute to the pathogenesis of inflammatory disease in lupus. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 29% |
| Mexico | 1 | 14% |
| Switzerland | 1 | 14% |
| Unknown | 3 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 86% |
| Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 156 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| Portugal | 1 | <1% |
| Unknown | 154 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 23 | 15% |
| Student > Ph. D. Student | 22 | 14% |
| Researcher | 15 | 10% |
| Student > Master | 15 | 10% |
| Other | 14 | 9% |
| Other | 23 | 15% |
| Unknown | 44 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 30 | 19% |
| Biochemistry, Genetics and Molecular Biology | 24 | 15% |
| Immunology and Microbiology | 20 | 13% |
| Agricultural and Biological Sciences | 18 | 12% |
| Chemistry | 5 | 3% |
| Other | 12 | 8% |
| Unknown | 47 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2023.
All research outputs
#1,503,704
of 25,593,129 outputs
Outputs from Frontiers in immunology
#1,325
of 32,040 outputs
Outputs of similar age
#18,518
of 279,603 outputs
Outputs of similar age from Frontiers in immunology
#6
of 181 outputs
Altmetric has tracked 25,593,129 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 32,040 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,603 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 181 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.