Title |
Guardians of the Gut – Murine Intestinal Macrophages and Dendritic Cells
|
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Published in |
Frontiers in immunology, June 2015
|
DOI | 10.3389/fimmu.2015.00254 |
Pubmed ID | |
Authors |
Mor Gross, Tomer-Meir Salame, Steffen Jung |
Abstract |
Intestinal mononuclear phagocytes find themselves in a unique environment, most prominently characterized by its constant exposure to commensal microbiota and food antigens. This anatomic setting has resulted in a number of specializations of the intestinal mononuclear phagocyte compartment that collectively contribute the unique steady state immune landscape of the healthy gut, including homeostatic innate lymphoid cells, B, and T cell compartments. As in other organs, macrophages and dendritic cells (DCs) orchestrate in addition the immune defense against pathogens, both in lymph nodes and mucosa-associated lymphoid tissue. Here, we will discuss origins and functions of intestinal DCs and macrophages and their respective subsets, focusing largely on the mouse and cells residing in the lamina propria. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | <1% |
India | 1 | <1% |
Unknown | 271 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 70 | 26% |
Researcher | 58 | 21% |
Student > Master | 30 | 11% |
Student > Doctoral Student | 16 | 6% |
Student > Bachelor | 16 | 6% |
Other | 46 | 17% |
Unknown | 38 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 76 | 28% |
Agricultural and Biological Sciences | 73 | 27% |
Biochemistry, Genetics and Molecular Biology | 29 | 11% |
Medicine and Dentistry | 29 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 2% |
Other | 16 | 6% |
Unknown | 46 | 17% |