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Regulation of NKT Cell Localization in Homeostasis and Infection

Overview of attention for article published in Frontiers in immunology, May 2015
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Title
Regulation of NKT Cell Localization in Homeostasis and Infection
Published in
Frontiers in immunology, May 2015
DOI 10.3389/fimmu.2015.00255
Pubmed ID
Authors

Drew Slauenwhite, Brent Johnston

Abstract

Natural killer T (NKT) cells are a specialized subset of T lymphocytes that regulate immune responses in the context of autoimmunity, cancer, and microbial infection. Lipid antigens derived from bacteria, parasites, and fungi can be presented by CD1d molecules and recognized by the canonical T cell receptors on NKT cells. Alternatively, NKT cells can be activated through recognition of self-lipids and/or pro-inflammatory cytokines generated during infection. Unlike conventional T cells, only a small subset of NKT cells traffic through the lymph nodes under homeostatic conditions, with the largest NKT cell populations localizing to the liver, lungs, spleen, and bone marrow. This is thought to be mediated by differences in chemokine receptor expression profiles. However, the impact of infection on the tissue localization and function of NKT remains largely unstudied. This review focuses on the mechanisms mediating the establishment of peripheral NKT cell populations during homeostasis and how tissue localization of NKT cells is affected during infection.

X Demographics

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The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 177 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Germany 1 <1%
Switzerland 1 <1%
Canada 1 <1%
Unknown 173 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 39 22%
Researcher 32 18%
Student > Bachelor 18 10%
Student > Master 17 10%
Student > Doctoral Student 13 7%
Other 22 12%
Unknown 36 20%
Readers by discipline Count As %
Immunology and Microbiology 49 28%
Agricultural and Biological Sciences 32 18%
Biochemistry, Genetics and Molecular Biology 22 12%
Medicine and Dentistry 22 12%
Nursing and Health Professions 2 1%
Other 10 6%
Unknown 40 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2017.
All research outputs
#16,721,717
of 25,374,647 outputs
Outputs from Frontiers in immunology
#18,323
of 31,516 outputs
Outputs of similar age
#158,639
of 280,163 outputs
Outputs of similar age from Frontiers in immunology
#110
of 180 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,516 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,163 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 180 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.