Title |
Regulation of NKT Cell Localization in Homeostasis and Infection
|
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Published in |
Frontiers in immunology, May 2015
|
DOI | 10.3389/fimmu.2015.00255 |
Pubmed ID | |
Authors |
Drew Slauenwhite, Brent Johnston |
Abstract |
Natural killer T (NKT) cells are a specialized subset of T lymphocytes that regulate immune responses in the context of autoimmunity, cancer, and microbial infection. Lipid antigens derived from bacteria, parasites, and fungi can be presented by CD1d molecules and recognized by the canonical T cell receptors on NKT cells. Alternatively, NKT cells can be activated through recognition of self-lipids and/or pro-inflammatory cytokines generated during infection. Unlike conventional T cells, only a small subset of NKT cells traffic through the lymph nodes under homeostatic conditions, with the largest NKT cell populations localizing to the liver, lungs, spleen, and bone marrow. This is thought to be mediated by differences in chemokine receptor expression profiles. However, the impact of infection on the tissue localization and function of NKT remains largely unstudied. This review focuses on the mechanisms mediating the establishment of peripheral NKT cell populations during homeostasis and how tissue localization of NKT cells is affected during infection. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 20% |
Switzerland | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | <1% |
Germany | 1 | <1% |
Switzerland | 1 | <1% |
Canada | 1 | <1% |
Unknown | 173 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 39 | 22% |
Researcher | 32 | 18% |
Student > Bachelor | 18 | 10% |
Student > Master | 17 | 10% |
Student > Doctoral Student | 13 | 7% |
Other | 22 | 12% |
Unknown | 36 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 49 | 28% |
Agricultural and Biological Sciences | 32 | 18% |
Biochemistry, Genetics and Molecular Biology | 22 | 12% |
Medicine and Dentistry | 22 | 12% |
Nursing and Health Professions | 2 | 1% |
Other | 10 | 6% |
Unknown | 40 | 23% |