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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Lipid Raft-Mediated Regulation of Hyaluronan–CD44 Interactions in Inflammation and Cancer
|
|---|---|
| Published in |
Frontiers in immunology, August 2015
|
| DOI | 10.3389/fimmu.2015.00420 |
| Pubmed ID | |
| Authors |
Toshiyuki Murai |
| Abstract |
Hyaluronan is a major component of the extracellular matrix and plays pivotal roles in inflammation and cancer. Hyaluronan oligomers are frequently found in these pathological conditions, in which they exert their effects via association with the transmembrane receptor CD44. Lipid rafts are cholesterol- and glycosphingolipid-enriched membrane microdomains that may regulate membrane receptors while serving as platforms for transmembrane signaling at the cell surface. This article focuses on the recent discovery that lipid rafts regulate the interaction between CD44 and hyaluronan, which depends largely on hyaluronan's size. Lipid rafts regulate CD44's ability to bind hyaluronan in T cells, control the rolling adhesion of lymphocytes on vascular endothelial cells, and regulate hyaluronan- and CD44-mediated cancer cell migration. The implications of these findings for preventing inflammatory disorders and cancer are also discussed. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 1% |
| Malaysia | 1 | 1% |
| Portugal | 1 | 1% |
| Unknown | 73 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 25% |
| Student > Ph. D. Student | 10 | 13% |
| Student > Bachelor | 8 | 11% |
| Student > Master | 7 | 9% |
| Student > Doctoral Student | 6 | 8% |
| Other | 16 | 21% |
| Unknown | 10 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 24% |
| Biochemistry, Genetics and Molecular Biology | 15 | 20% |
| Medicine and Dentistry | 8 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 7% |
| Immunology and Microbiology | 5 | 7% |
| Other | 10 | 13% |
| Unknown | 15 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2015.
All research outputs
#20,655,488
of 25,371,288 outputs
Outputs from Frontiers in immunology
#24,734
of 31,513 outputs
Outputs of similar age
#203,632
of 277,474 outputs
Outputs of similar age from Frontiers in immunology
#119
of 152 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,513 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,474 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 152 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.