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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Cellular Prion Protein: A Player in Immunological Quiescence
|
|---|---|
| Published in |
Frontiers in immunology, September 2015
|
| DOI | 10.3389/fimmu.2015.00450 |
| Pubmed ID | |
| Authors |
Maren K. Bakkebø, Sophie Mouillet-Richard, Arild Espenes, Wilfred Goldmann, Jörg Tatzelt, Michael A. Tranulis |
| Abstract |
Despite intensive studies since the 1990s, the physiological role of the cellular prion protein (PrP(C)) remains elusive. Here, we present a novel concept suggesting that PrP(C) contributes to immunological quiescence in addition to cell protection. PrP(C) is highly expressed in diverse organs that by multiple means are particularly protected from inflammation, such as the brain, eye, placenta, pregnant uterus, and testes, while at the same time it is expressed in most cells of the lymphoreticular system. In this paradigm, PrP(C) serves two principal roles: to modulate the inflammatory potential of immune cells and to protect vulnerable parenchymal cells against noxious insults generated through inflammation. Here, we review studies of PrP(C) physiology in view of this concept. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| United Kingdom | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 74 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 25% |
| Researcher | 13 | 17% |
| Student > Bachelor | 10 | 13% |
| Student > Postgraduate | 7 | 9% |
| Student > Doctoral Student | 6 | 8% |
| Other | 11 | 14% |
| Unknown | 10 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 20 | 26% |
| Biochemistry, Genetics and Molecular Biology | 17 | 22% |
| Medicine and Dentistry | 8 | 11% |
| Neuroscience | 8 | 11% |
| Immunology and Microbiology | 4 | 5% |
| Other | 8 | 11% |
| Unknown | 11 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2015.
All research outputs
#14,599,159
of 25,371,288 outputs
Outputs from Frontiers in immunology
#12,358
of 31,507 outputs
Outputs of similar age
#127,652
of 277,043 outputs
Outputs of similar age from Frontiers in immunology
#52
of 160 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,507 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,043 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 160 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.