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Development and Function of Protective and Pathologic Memory CD4 T Cells

Overview of attention for article published in Frontiers in immunology, September 2015
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Title
Development and Function of Protective and Pathologic Memory CD4 T Cells
Published in
Frontiers in immunology, September 2015
DOI 10.3389/fimmu.2015.00456
Pubmed ID
Authors

Shafqat Ahrar Jaigirdar, Megan K. L. MacLeod

Abstract

Immunological memory is one of the defining features of the adaptive immune system. As key orchestrators and mediators of immunity, CD4 T cells are central to the vast majority of adaptive immune responses. Generated following an immune response, memory CD4 T cells retain pertinent information about their activation environment enabling them to make rapid effector responses upon reactivation. These responses can either benefit the host by hastening the control of pathogens or cause damaging immunopathology. Here, we will discuss the diversity of the memory CD4 T cell pool, the signals that influence the transition of activated T cells into that pool, and highlight how activation requirements differ between naïve and memory CD4 T cells. A greater understanding of these factors has the potential to aid the design of more effective vaccines and to improve regulation of pathologic CD4 T cells, such as in the context of autoimmunity and allergy.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 123 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 33 27%
Researcher 23 19%
Student > Master 17 14%
Student > Bachelor 11 9%
Student > Doctoral Student 10 8%
Other 14 11%
Unknown 15 12%
Readers by discipline Count As %
Immunology and Microbiology 39 32%
Agricultural and Biological Sciences 21 17%
Biochemistry, Genetics and Molecular Biology 17 14%
Medicine and Dentistry 14 11%
Pharmacology, Toxicology and Pharmaceutical Science 3 2%
Other 12 10%
Unknown 17 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2015.
All research outputs
#20,027,150
of 25,477,125 outputs
Outputs from Frontiers in immunology
#22,697
of 31,773 outputs
Outputs of similar age
#191,863
of 280,068 outputs
Outputs of similar age from Frontiers in immunology
#106
of 160 outputs
Altmetric has tracked 25,477,125 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,773 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,068 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 160 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.