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X Demographics
Mendeley readers
Attention Score in Context
| Title |
CD74 in Kidney Disease
|
|---|---|
| Published in |
Frontiers in immunology, September 2015
|
| DOI | 10.3389/fimmu.2015.00483 |
| Pubmed ID | |
| Authors |
Lara Valiño-Rivas, Ciro Baeza-Bermejillo, Laura Gonzalez-Lafuente, Ana Belen Sanz, Alberto Ortiz, Maria Dolores Sanchez-Niño |
| Abstract |
CD74 (invariant MHC class II) regulates protein trafficking and is a receptor for macrophage migration inhibitory factor (MIF) and d-dopachrome tautomerase (d-DT/MIF-2). CD74 expression is increased in tubular cells and/or glomerular podocytes and parietal cells in human metabolic nephropathies, polycystic kidney disease, graft rejection and kidney cancer and in experimental diabetic nephropathy and glomerulonephritis. Stressors like abnormal metabolite (glucose, lyso-Gb3) levels and inflammatory cytokines increase kidney cell CD74. MIF activates CD74 to increase inflammatory cytokines in podocytes and tubular cells and proliferation in glomerular parietal epithelial cells and cyst cells. MIF overexpression promotes while MIF targeting protects from experimental glomerular injury and kidney cysts, and interference with MIF/CD74 signaling or CD74 deficiency protected from crescentic glomerulonephritis. However, CD74 may protect from interstitial kidney fibrosis. Furthermore, CD74 expression by stressed kidney cells raises questions about the kidney safety of cancer therapy strategies delivering lethal immunoconjugates to CD74-expressing cells. Thus, understanding CD74 biology in kidney cells is relevant for kidney therapeutics. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 13% |
| Puerto Rico | 1 | 13% |
| Spain | 1 | 13% |
| United Kingdom | 1 | 13% |
| Switzerland | 1 | 13% |
| Unknown | 3 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 88% |
| Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Costa Rica | 1 | 2% |
| Unknown | 61 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 26% |
| Researcher | 7 | 11% |
| Student > Postgraduate | 5 | 8% |
| Professor > Associate Professor | 4 | 6% |
| Student > Master | 4 | 6% |
| Other | 10 | 16% |
| Unknown | 16 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 23% |
| Biochemistry, Genetics and Molecular Biology | 11 | 18% |
| Agricultural and Biological Sciences | 6 | 10% |
| Immunology and Microbiology | 3 | 5% |
| Neuroscience | 2 | 3% |
| Other | 6 | 10% |
| Unknown | 20 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2022.
All research outputs
#5,400,472
of 25,374,917 outputs
Outputs from Frontiers in immunology
#6,060
of 31,520 outputs
Outputs of similar age
#65,256
of 286,059 outputs
Outputs of similar age from Frontiers in immunology
#27
of 161 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,520 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,059 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 161 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.