Title |
Ontogeny of Tissue-Resident Macrophages
|
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Published in |
Frontiers in immunology, September 2015
|
DOI | 10.3389/fimmu.2015.00486 |
Pubmed ID | |
Authors |
Guillaume Hoeffel, Florent Ginhoux |
Abstract |
The origin of tissue-resident macrophages, crucial for homeostasis and immunity, has remained controversial until recently. Originally described as part of the mononuclear phagocyte system, macrophages were long thought to derive solely from adult blood circulating monocytes. However, accumulating evidence now shows that certain macrophage populations are in fact independent from monocyte and even from adult bone marrow hematopoiesis. These tissue-resident macrophages derive from sequential seeding of tissues by two precursors during embryonic development. Primitive macrophages generated in the yolk sac (YS) from early erythro-myeloid progenitors (EMPs), independently of the transcription factor c-Myb and bypassing monocytic intermediates, first give rise to microglia. Later, fetal monocytes, generated from c-Myb(+) EMPs that initially seed the fetal liver (FL), then give rise to the majority of other adult macrophages. Thus, hematopoietic stem cell-independent embryonic precursors transiently present in the YS and the FL give rise to long-lasting self-renewing macrophage populations. |
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Geographical breakdown
Country | Count | As % |
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United States | 2 | 33% |
Switzerland | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 3 | 50% |
Members of the public | 3 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | <1% |
United States | 1 | <1% |
Germany | 1 | <1% |
Canada | 1 | <1% |
Unknown | 505 | 99% |
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Researcher | 80 | 16% |
Student > Bachelor | 63 | 12% |
Student > Master | 53 | 10% |
Student > Doctoral Student | 34 | 7% |
Other | 59 | 12% |
Unknown | 99 | 19% |
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Neuroscience | 44 | 9% |
Other | 39 | 8% |
Unknown | 100 | 20% |