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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Timing of T Cell Priming and Cycling
|
|---|---|
| Published in |
Frontiers in immunology, November 2015
|
| DOI | 10.3389/fimmu.2015.00563 |
| Pubmed ID | |
| Authors |
Reinhard Obst |
| Abstract |
The proliferation of specific lymphocytes is the central tenet of the clonal selection paradigm. Antigen recognition by T cells triggers a series of events that produces expanded clones of differentiated effector cells. TCR signaling events are detectable within seconds and minutes and are likely to continue for hours and days in vivo. Here, I review the work done on the importance of TCR signals in the later part of the expansion phase of the primary T cell response, primarily regarding the regulation of the cell cycle in CD4(+) and CD8(+) cells. The results suggest a degree of programing by early signals for effector differentiation, particularly in the CD8(+) T cell compartment, with optimal expansion supported by persistent antigen presentation later on. Differences to CD4(+) T cell expansion and new avenues toward a molecular understanding of cell cycle regulation in lymphocytes are discussed. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Romania | 1 | 33% |
| United States | 1 | 33% |
| Switzerland | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 239 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 3 | 1% |
| United States | 1 | <1% |
| Russia | 1 | <1% |
| Belgium | 1 | <1% |
| Unknown | 233 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 67 | 28% |
| Researcher | 37 | 15% |
| Student > Master | 30 | 13% |
| Student > Bachelor | 18 | 8% |
| Student > Doctoral Student | 12 | 5% |
| Other | 36 | 15% |
| Unknown | 39 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 65 | 27% |
| Agricultural and Biological Sciences | 43 | 18% |
| Biochemistry, Genetics and Molecular Biology | 29 | 12% |
| Medicine and Dentistry | 18 | 8% |
| Engineering | 7 | 3% |
| Other | 32 | 13% |
| Unknown | 45 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2015.
All research outputs
#15,875,393
of 25,576,801 outputs
Outputs from Frontiers in immunology
#15,558
of 31,990 outputs
Outputs of similar age
#153,290
of 297,414 outputs
Outputs of similar age from Frontiers in immunology
#82
of 155 outputs
Altmetric has tracked 25,576,801 research outputs across all sources so far. This one is in the 36th percentile – i.e., 36% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,990 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 297,414 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 155 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.