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The Interplay Between Monocytes/Macrophages and CD4+ T Cell Subsets in Rheumatoid Arthritis

Overview of attention for article published in Frontiers in immunology, November 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

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1 blog
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264 Mendeley
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Title
The Interplay Between Monocytes/Macrophages and CD4+ T Cell Subsets in Rheumatoid Arthritis
Published in
Frontiers in immunology, November 2015
DOI 10.3389/fimmu.2015.00571
Pubmed ID
Authors

Ceri A. Roberts, Abigail K. Dickinson, Leonie S. Taams

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by inflammation of the synovial lining (synovitis). The inflammation in the RA joint is associated with and driven by immune cell infiltration, synovial hyperproliferation, and excessive production of proinflammatory mediators, such as tumor necrosis factor α (TNFα), interferon γ (IFNγ), interleukin (IL)-1β, IL-6, and IL-17, eventually resulting in damage to the cartilage and underlying bone. The RA joint harbors a wide range of immune cell types, including monocytes, macrophages, and CD4(+) T cells (both proinflammatory and regulatory). The interplay between CD14(+) myeloid cells and CD4(+) T cells can significantly influence CD4(+) T cell function, and conversely, effector vs. regulatory CD4(+) T cell subsets can exert profound effects on monocyte/macrophage function. In this review, we will discuss how the interplay between CD4(+) T cells and monocytes/macrophages may contribute to the immunopathology of RA.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 264 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Bulgaria 1 <1%
Brazil 1 <1%
United Kingdom 1 <1%
Korea, Republic of 1 <1%
Unknown 259 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 64 24%
Student > Bachelor 34 13%
Researcher 32 12%
Student > Master 28 11%
Student > Doctoral Student 19 7%
Other 39 15%
Unknown 48 18%
Readers by discipline Count As %
Immunology and Microbiology 63 24%
Medicine and Dentistry 41 16%
Agricultural and Biological Sciences 39 15%
Biochemistry, Genetics and Molecular Biology 36 14%
Pharmacology, Toxicology and Pharmaceutical Science 7 3%
Other 26 10%
Unknown 52 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 October 2019.
All research outputs
#3,797,142
of 25,371,288 outputs
Outputs from Frontiers in immunology
#4,299
of 31,513 outputs
Outputs of similar age
#59,892
of 392,478 outputs
Outputs of similar age from Frontiers in immunology
#16
of 137 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,513 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 392,478 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 137 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.