Title |
Comparative Anatomy of Phagocytic and Immunological Synapses
|
---|---|
Published in |
Frontiers in immunology, January 2016
|
DOI | 10.3389/fimmu.2016.00018 |
Pubmed ID | |
Authors |
Florence Niedergang, Vincenzo Di Bartolo, Andrés Alcover |
Abstract |
The generation of phagocytic cups and immunological synapses are crucial events of the innate and adaptive immune responses, respectively. They are triggered by distinct immune receptors and performed by different cell types. However, growing experimental evidence shows that a very close series of molecular and cellular events control these two processes. Thus, the tight and dynamic interplay between receptor signaling, actin and microtubule cytoskeleton, and targeted vesicle traffic are all critical features to build functional phagosomes and immunological synapses. Interestingly, both phagocytic cups and immunological synapses display particular spatial and temporal patterns of receptors and signaling molecules, leading to the notion of "phagocytic synapse." Here, we discuss both types of structures, their organization, and the mechanisms by which they are generated and regulated. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 109 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 22 | 20% |
Student > Ph. D. Student | 19 | 17% |
Professor | 13 | 12% |
Student > Master | 10 | 9% |
Student > Doctoral Student | 6 | 6% |
Other | 19 | 17% |
Unknown | 20 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 27 | 25% |
Immunology and Microbiology | 26 | 24% |
Biochemistry, Genetics and Molecular Biology | 14 | 13% |
Medicine and Dentistry | 5 | 5% |
Physics and Astronomy | 5 | 5% |
Other | 7 | 6% |
Unknown | 25 | 23% |