Title |
Human NK Cell Diversity in Viral Infection: Ramifications of Ramification
|
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Published in |
Frontiers in immunology, March 2016
|
DOI | 10.3389/fimmu.2016.00066 |
Pubmed ID | |
Authors |
Dara M. Strauss-Albee, Catherine A. Blish |
Abstract |
Natural killer (NK) cells are a unique lymphocyte lineage with remarkable agility in the rapid destruction of virus-infected cells. They are also the most poorly understood class of lymphocyte. A spectrum of activating and inhibitory receptors at the NK cell surface leads to an unusual and difficult-to-study mechanism of cellular recognition, as well as a very high capacity for diversity at the single-cell level. Here, we review the evidence for the role of NK cells in the earliest stage of human viral infection, and in its prevention. We argue that single-cell diversity is a logical evolutionary adaptation for their position in the immune response and contributes to their ability to kill virus-infected cells. Finally, we look to the future, where emerging single-cell technologies will enable a new generation of rigorous and clinically relevant studies on NK cells accounting for all of their unique and diverse characteristics. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 17% |
United States | 1 | 17% |
United Kingdom | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
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Members of the public | 4 | 67% |
Scientists | 1 | 17% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 40 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 23% |
Student > Ph. D. Student | 6 | 15% |
Student > Doctoral Student | 5 | 13% |
Other | 5 | 13% |
Professor | 2 | 5% |
Other | 5 | 13% |
Unknown | 8 | 20% |
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Medicine and Dentistry | 2 | 5% |
Physics and Astronomy | 1 | 3% |
Other | 1 | 3% |
Unknown | 8 | 20% |