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X Demographics
Mendeley readers
Attention Score in Context
| Title |
T Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T Cells
|
|---|---|
| Published in |
Frontiers in immunology, February 2016
|
| DOI | 10.3389/fimmu.2016.00076 |
| Pubmed ID | |
| Authors |
James M. Conley, Michael P. Gallagher, Leslie J. Berg |
| Abstract |
Signaling downstream of the T cell receptor (TCR) is directly regulated by the dose and affinity of peptide antigen. The strength of TCR signaling drives a multitude of T cell functions from development to differentiation. CD8 T cells differentiate into a diverse pool of effector and memory cells after activation, a process that is critical for pathogen clearance and is highly regulated by TCR signal strength. T cells rapidly alter their gene expression upon activation. Multiple signaling pathways downstream of the TCR activate transcription factors, which are critical for this process. The dynamics between proximal TCR signaling, transcription factor activation and CD8 T cell function are discussed here. We propose that inducible T cell kinase (ITK) acts as a rheostat for gene expression. This unique regulation of TCR signaling by ITK provides a possible signaling mechanism for the promotion of a diverse T cell repertoire in response to pathogen. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iran, Islamic Republic of | 1 | 17% |
| United States | 1 | 17% |
| Denmark | 1 | 17% |
| Switzerland | 1 | 17% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 67% |
| Practitioners (doctors, other healthcare professionals) | 2 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 207 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 205 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 58 | 28% |
| Researcher | 29 | 14% |
| Student > Bachelor | 19 | 9% |
| Student > Master | 15 | 7% |
| Other | 9 | 4% |
| Other | 23 | 11% |
| Unknown | 54 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 45 | 22% |
| Agricultural and Biological Sciences | 43 | 21% |
| Biochemistry, Genetics and Molecular Biology | 36 | 17% |
| Medicine and Dentistry | 7 | 3% |
| Chemistry | 4 | 2% |
| Other | 15 | 7% |
| Unknown | 57 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2019.
All research outputs
#6,402,167
of 25,461,852 outputs
Outputs from Frontiers in immunology
#6,647
of 31,698 outputs
Outputs of similar age
#82,718
of 312,230 outputs
Outputs of similar age from Frontiers in immunology
#24
of 144 outputs
Altmetric has tracked 25,461,852 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 31,698 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,230 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 144 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.