Title |
“Natural Regulators”: NK Cells as Modulators of T Cell Immunity
|
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Published in |
Frontiers in immunology, June 2016
|
DOI | 10.3389/fimmu.2016.00235 |
Pubmed ID | |
Authors |
Iona S. Schuster, Jerome D. Coudert, Christopher E. Andoniou, Mariapia A. Degli-Esposti |
Abstract |
Natural killer (NK) cells are known as frontline responders capable of rapidly mediating a response upon encountering transformed or infected cells. Recent findings indicate that NK cells, in addition to acting as innate effectors, can also regulate adaptive immune responses. Here, we review recent studies on the immunoregulatory function of NK cells with a specific focus on their ability to affect the generation of early, as well as long-term antiviral T cell responses, and their role in modulating immune pathology and disease. In addition, we summarize the current knowledge of the factors governing regulatory NK cell responses and discuss origin, tissue specificity, and open questions about the classification of regulatory NK cells as classical NK cells versus group 1 innate lymphoid cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 17% |
France | 1 | 17% |
Unknown | 4 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 140 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 24 | 17% |
Student > Ph. D. Student | 23 | 16% |
Researcher | 22 | 16% |
Student > Doctoral Student | 11 | 8% |
Student > Bachelor | 8 | 6% |
Other | 16 | 11% |
Unknown | 36 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 35 | 25% |
Agricultural and Biological Sciences | 25 | 18% |
Biochemistry, Genetics and Molecular Biology | 21 | 15% |
Medicine and Dentistry | 14 | 10% |
Engineering | 2 | 1% |
Other | 6 | 4% |
Unknown | 37 | 26% |