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X Demographics
Mendeley readers
Attention Score in Context
| Title |
ICOS Co-Stimulation: Friend or Foe?
|
|---|---|
| Published in |
Frontiers in immunology, August 2016
|
| DOI | 10.3389/fimmu.2016.00304 |
| Pubmed ID | |
| Authors |
Daniel J. Wikenheiser, Jason S. Stumhofer |
| Abstract |
Over the last 15 years, the inducible T cell co-stimulator (ICOS) has been implicated in various immune outcomes, including the induction and regulation of Th1, Th2, and Th17 immunity. In addition to its role in directing effector T cell differentiation, ICOS has also been consistently linked with the induction of thymus-dependent (TD) antibody (Ab) responses and the germinal center (GC) reaction. ICOS co-stimulation, therefore, appears to play a complex role in dictating the course of adaptive immunity. In this article, we summarize the initial characterization of ICOS and its relationship with the related co-stimulatory molecule CD28. We then address the contribution of ICOS in directing an effector T cell response, and ultimately disease outcome, against various bacterial, viral, and parasitic infections. Next, we assess ICOS in the context of TD Ab responses, connecting ICOS signaling to follicular helper T cell differentiation and its role in the GC reaction. Finally, we address the link between ICOS and human autoimmune disorders and evaluate potential therapies aiming to mitigate disease progression by modulating ICOS signaling. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 295 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | <1% |
| Unknown | 294 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 51 | 17% |
| Student > Ph. D. Student | 49 | 17% |
| Researcher | 43 | 15% |
| Student > Bachelor | 27 | 9% |
| Student > Doctoral Student | 15 | 5% |
| Other | 40 | 14% |
| Unknown | 70 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 79 | 27% |
| Biochemistry, Genetics and Molecular Biology | 45 | 15% |
| Agricultural and Biological Sciences | 32 | 11% |
| Medicine and Dentistry | 31 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 2% |
| Other | 26 | 9% |
| Unknown | 75 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2023.
All research outputs
#2,977,949
of 25,394,764 outputs
Outputs from Frontiers in immunology
#3,059
of 31,554 outputs
Outputs of similar age
#51,486
of 371,499 outputs
Outputs of similar age from Frontiers in immunology
#11
of 129 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,554 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 371,499 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 129 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.