Title |
Comparative Analysis of Immune Activation Markers of CD8+ T Cells in Lymph Nodes of Different Origins in SIV-Infected Chinese Rhesus Macaques
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Published in |
Frontiers in immunology, September 2016
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DOI | 10.3389/fimmu.2016.00371 |
Pubmed ID | |
Authors |
Jinbiao Liu, Qianhao Xiao, Runhong Zhou, Yong Wang, Qiaoyang Xian, Tongcui Ma, Ke Zhuang, Li Zhou, Deyin Guo, Xu Wang, Wen-Zhe Ho, Jieliang Li |
Abstract |
Altered T-cell homeostasis, such as expansion of CD8(+) T cells to the secondary lymphatic compartments, has been suggested as a mechanism of HIV/simian immunodeficiency virus (SIV)-pathogenesis. However, the role of immune activation of CD8(+) T cells in the CD4/CD8 turnover and viral replication in these tissues is not completely understood. In this study, we compared the expression of immune activation markers (CD69 and HLA-DR) on CD8(+) T cells in the peripheral blood and lymph nodes (LNs) of SIV-infected/uninfected Chinese rhesus macaques. SIV-infected macaques had significantly higher percentages of CD8(+)CD69(+) and CD8(+)HLA-DR(+) T cells in all these anatomical compartments than uninfected macaques. LNs that located close to the gastrointestinal (GI) tract (colon, mesenteric, and iliac LNs) of SIV-infected macaques had profoundly lower numbers of CD4(+) T cells, but no significant difference in expression of activation marker (CD8(+)CD69(+) and CD8(+)HLA-DR(+)) as compared with the peripheral lymphatic tissues (axillary and inguinal LNs). The CD4/CD8 ratios were negatively correlated with the activation of CD8(+) T cells in the overall LNs, with further associations with CD8(+)HLA-DR(+) in GI LNs while CD8(+)CD69(+) in peripheral LNs. These observations demonstrate that the increase of CD8(+) T cell activation is a contributing factor for the decline of CD4/CD8 ratios in GI system. |
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