Title |
Fas Versatile Signaling and Beyond: Pivotal Role of Tyrosine Phosphorylation in Context-Dependent Signaling and Diseases
|
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Published in |
Frontiers in immunology, October 2016
|
DOI | 10.3389/fimmu.2016.00429 |
Pubmed ID | |
Authors |
Krittalak Chakrabandhu, Anne-Odile Hueber |
Abstract |
The Fas/FasL system is known, first and foremost, as a potent apoptosis activator. While its proapoptotic features have been studied extensively, evidence that the Fas/FasL system can elicit non-death signals has also accumulated. These non-death signals can promote survival, proliferation, migration, and invasion of cells. The key molecular mechanism that determines the shift from cell death to non-death signals had remained unclear until the recent identification of the tyrosine phosphorylation in the death domain of Fas as the reversible signaling switch. In this review, we present the connection between the recent findings regarding the control of Fas multi-signals and the context-dependent signaling choices. This information can help explain variable roles of Fas signaling pathway in different pathologies. |
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Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 43% |
Researcher | 2 | 14% |
Student > Bachelor | 1 | 7% |
Student > Doctoral Student | 1 | 7% |
Student > Master | 1 | 7% |
Other | 1 | 7% |
Unknown | 2 | 14% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 2 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
Physics and Astronomy | 1 | 7% |
Immunology and Microbiology | 1 | 7% |
Other | 2 | 14% |
Unknown | 2 | 14% |