Title |
Interleukin-27 Early Impacts Leishmania infantum Infection in Mice and Correlates with Active Visceral Disease in Humans
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Published in |
Frontiers in immunology, November 2016
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DOI | 10.3389/fimmu.2016.00478 |
Pubmed ID | |
Authors |
Begoña Pérez-Cabezas, Pedro Cecílio, Ana Luisa Robalo, Ricardo Silvestre, Eugenia Carrillo, Javier Moreno, Juan V. San Martín, Rita Vasconcellos, Anabela Cordeiro-da-Silva |
Abstract |
The complexity of Leishmania-host interactions, one of the main leishmaniasis issues, is yet to be fully understood. We detected elevated IL-27 plasma levels in European patients with active visceral disease caused by Leishmania infantum, which returned to basal levels after successful treatment, suggesting this cytokine as a probable infection mediator. We further addressed this hypothesis recurring to two classical susceptible visceral leishmaniasis mouse models. BALB/c, but not C57BL/6 mice, showed increased IL-27 systemic levels after infection, which was associated with an upregulation of IL-27p28 expression by dendritic cells and higher parasite burdens. Neutralization of IL-27 in acutely infected BALB/c led to decreased parasite burdens and a transient increase in IFN-γ(+) splenic T cells, while administration of IL-27 to C57BL/6 promoted a local anti-inflammatory cytokine response at the site of infection and increased parasite loads. Overall, we show that, as in humans, BALB/c IL-27 systemic levels are infection dependently upregulated and may favor parasite installation by controlling inflammation. |
X Demographics
Geographical breakdown
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Portugal | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Brazil | 1 | 3% |
Unknown | 30 | 97% |
Demographic breakdown
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Student > Ph. D. Student | 8 | 26% |
Researcher | 6 | 19% |
Student > Master | 4 | 13% |
Student > Bachelor | 3 | 10% |
Student > Doctoral Student | 2 | 6% |
Other | 3 | 10% |
Unknown | 5 | 16% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 11 | 35% |
Medicine and Dentistry | 4 | 13% |
Agricultural and Biological Sciences | 4 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Nursing and Health Professions | 1 | 3% |
Other | 2 | 6% |
Unknown | 7 | 23% |