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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Immunological and Translational Aspects of NK Cell-Based Antitumor Immunotherapies
|
|---|---|
| Published in |
Frontiers in immunology, November 2016
|
| DOI | 10.3389/fimmu.2016.00492 |
| Pubmed ID | |
| Authors |
Maxim Shevtsov, Gabriele Multhoff |
| Abstract |
Natural killer (NK) cells play a pivotal role in the first line of defense against cancer. NK cells that are deficient in CD3 and a clonal T cell receptor (TCR) can be subdivided into two major subtypes, CD56(dim)CD16(+) cytotoxic and CD56(bright)CD16(-) immunoregulatory NK cells. Cytotoxic NK cells not only directly kill tumor cells without previous stimulation by cytotoxic effector molecules, such as perforin and granzymes or via death receptor interactions, but also act as regulatory cells for the immune system by secreting cytokines and chemokines. The aim of this review is to highlight therapeutic strategies utilizing autologous and allogenic NK cells, combinations of NK cells with monoclonal antibodies to induce antibody-dependent cellular cytotoxicity, or immune checkpoint inhibitors. Additionally, we discuss the use of chimeric antigen receptor-engineered NK cells in cancer immunotherapy. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 83 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 26% |
| Student > Ph. D. Student | 15 | 18% |
| Student > Bachelor | 9 | 11% |
| Student > Master | 7 | 8% |
| Other | 5 | 6% |
| Other | 11 | 13% |
| Unknown | 16 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 19 | 22% |
| Agricultural and Biological Sciences | 18 | 21% |
| Medicine and Dentistry | 12 | 14% |
| Biochemistry, Genetics and Molecular Biology | 11 | 13% |
| Neuroscience | 2 | 2% |
| Other | 4 | 5% |
| Unknown | 19 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 July 2019.
All research outputs
#7,960,052
of 25,374,647 outputs
Outputs from Frontiers in immunology
#9,536
of 31,516 outputs
Outputs of similar age
#109,757
of 316,731 outputs
Outputs of similar age from Frontiers in immunology
#90
of 247 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 31,516 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,731 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 247 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.