Title |
Recent Developments in Cellular Immunotherapy for HSCT-Associated Complications
|
---|---|
Published in |
Frontiers in immunology, November 2016
|
DOI | 10.3389/fimmu.2016.00500 |
Pubmed ID | |
Authors |
Monica Reis, Justyna Ogonek, Marsela Qesari, Nuno M. Borges, Lindsay Nicholson, Liane Preußner, Anne Mary Dickinson, Xiao-nong Wang, Eva M. Weissinger, Anne Richter |
Abstract |
Allogeneic hematopoietic stem cell transplantation is associated with serious complications, and improvement of the overall clinical outcome of patients with hematological malignancies is necessary. During the last decades, posttransplant donor-derived adoptive cellular immunotherapeutic strategies have been progressively developed for the treatment of graft-versus-host disease (GvHD), infectious complications, and tumor relapses. To date, the common challenge of all these cell-based approaches is their implementation for clinical application. Establishing an appropriate manufacturing process, to guarantee safe and effective therapeutics with simultaneous consideration of economic requirements is one of the most critical hurdles. In this review, we will discuss the recent scientific findings, clinical experiences, and technological advances for cell processing toward the application of mesenchymal stromal cells as a therapy for treatment of severe GvHD, virus-specific T cells for targeting life-threating infections, and of chimeric antigen receptors-engineered T cells to treat relapsed leukemia. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | 33% |
United States | 2 | 17% |
Spain | 1 | 8% |
Switzerland | 1 | 8% |
Unknown | 4 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 67% |
Practitioners (doctors, other healthcare professionals) | 3 | 25% |
Scientists | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
United States | 1 | 1% |
Unknown | 75 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 17% |
Student > Bachelor | 12 | 16% |
Researcher | 9 | 12% |
Student > Master | 6 | 8% |
Professor > Associate Professor | 5 | 6% |
Other | 17 | 22% |
Unknown | 15 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 19% |
Biochemistry, Genetics and Molecular Biology | 13 | 17% |
Agricultural and Biological Sciences | 9 | 12% |
Immunology and Microbiology | 6 | 8% |
Engineering | 4 | 5% |
Other | 12 | 16% |
Unknown | 18 | 23% |