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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cytotoxic CD4 T Cells: Differentiation, Function, and Application to Dengue Virus Infection
|
|---|---|
| Published in |
Frontiers in immunology, December 2016
|
| DOI | 10.3389/fimmu.2016.00531 |
| Pubmed ID | |
| Authors |
Yuan Tian, Alessandro Sette, Daniela Weiskopf |
| Abstract |
Dengue virus (DENV) has spread through most tropical and subtropical areas of the world and represents a serious public health problem. The control of DENV infection has not yet been fully successful due to lack of effective therapeutics or vaccines. Nevertheless, a better understanding of the immune responses against DENV infection may reveal new strategies for eliciting and improving antiviral immunity. T cells provide protective immunity against various viral infections by generating effector cells that cooperate to eliminate antigens and memory cells that can survive for long periods with enhanced abilities to control recurring pathogens. Following activation, CD8 T cells can migrate to sites of infection and kill infected cells, whereas CD4 T cells contribute to the elimination of pathogens by trafficking to infected tissues and providing help to innate immune responses, B cells, as well as CD8 T cells. However, it is now evident that CD4 T cells can also perform cytotoxic functions and induce the apoptosis of target cells. Importantly, accumulating studies demonstrate that cytotoxic CD4 T cells develop following DENV infections and may play a crucial role in protecting the host from severe dengue disease. We review our current understanding of the differentiation and function of cytotoxic CD4 T cells, with a focus on DENV infection, and discuss the potential of harnessing these cells for the prevention and treatment of DENV infection and disease. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 2 | 18% |
| Venezuela, Bolivarian Republic of | 2 | 18% |
| Mexico | 1 | 9% |
| Unknown | 6 | 55% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 82% |
| Practitioners (doctors, other healthcare professionals) | 2 | 18% |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 121 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 21% |
| Researcher | 21 | 17% |
| Student > Master | 21 | 17% |
| Student > Bachelor | 15 | 12% |
| Student > Doctoral Student | 6 | 5% |
| Other | 8 | 7% |
| Unknown | 24 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 38 | 31% |
| Agricultural and Biological Sciences | 19 | 16% |
| Biochemistry, Genetics and Molecular Biology | 18 | 15% |
| Medicine and Dentistry | 14 | 12% |
| Engineering | 3 | 2% |
| Other | 8 | 7% |
| Unknown | 21 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 December 2016.
All research outputs
#6,212,396
of 25,374,647 outputs
Outputs from Frontiers in immunology
#6,258
of 31,520 outputs
Outputs of similar age
#102,773
of 420,175 outputs
Outputs of similar age from Frontiers in immunology
#57
of 263 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,520 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 420,175 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 263 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.