Title |
Biomarker Tools to Design Clinical Vaccines Determined from a Study of Annual Listeriosis Incidence in Northern Spain
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Published in |
Frontiers in immunology, November 2016
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DOI | 10.3389/fimmu.2016.00541 |
Pubmed ID | |
Authors |
Ricardo Calderon-Gonzalez, Hector Teran-Navarro, José María Marimon, Claudia González-Rico, Jorge Calvo-Montes, Elisabet Frande-Cabanes, Miriam Alkorta-Gurrutxaga, M. C. Fariñas, Luis Martínez-Martínez, Emilio Perez-Trallero, Carmen Alvarez-Dominguez |
Abstract |
Two regions of northern Spain, Gipuzkoa, and Cantabria present high annual incidence of listeriosis (1.86 and 1.71 cases per 100,000 inhabitants, respectively). We report that the high annual incidences are a consequence of infection with highly virulent Listeria monocytogenes isolates linked to fatal outcomes in elderly patients with cancer. In addition, listeriosis patients with cancer present low IL-17A/IL-6 ratios and significantly reduced levels of anti-GAPDH1-22 antibodies, identified as two novel biomarkers of poor prognosis. Analysis of these biomarkers may aid in reducing the incidence of listeriosis. Moreover, GAPDH1-22-activated monocyte-derived dendritic cells of listeriosis patients with cancer seem useful tools to prepare clinical vaccines as they produce mainly Th1 cytokines. |
X Demographics
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Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 3 | 14% |
Student > Doctoral Student | 3 | 14% |
Student > Bachelor | 2 | 10% |
Student > Ph. D. Student | 2 | 10% |
Other | 1 | 5% |
Other | 4 | 19% |
Unknown | 6 | 29% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 4 | 19% |
Agricultural and Biological Sciences | 4 | 19% |
Nursing and Health Professions | 2 | 10% |
Environmental Science | 1 | 5% |
Unspecified | 1 | 5% |
Other | 3 | 14% |
Unknown | 6 | 29% |