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Biomarker Tools to Design Clinical Vaccines Determined from a Study of Annual Listeriosis Incidence in Northern Spain

Overview of attention for article published in Frontiers in immunology, November 2016
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Title
Biomarker Tools to Design Clinical Vaccines Determined from a Study of Annual Listeriosis Incidence in Northern Spain
Published in
Frontiers in immunology, November 2016
DOI 10.3389/fimmu.2016.00541
Pubmed ID
Authors

Ricardo Calderon-Gonzalez, Hector Teran-Navarro, José María Marimon, Claudia González-Rico, Jorge Calvo-Montes, Elisabet Frande-Cabanes, Miriam Alkorta-Gurrutxaga, M. C. Fariñas, Luis Martínez-Martínez, Emilio Perez-Trallero, Carmen Alvarez-Dominguez

Abstract

Two regions of northern Spain, Gipuzkoa, and Cantabria present high annual incidence of listeriosis (1.86 and 1.71 cases per 100,000 inhabitants, respectively). We report that the high annual incidences are a consequence of infection with highly virulent Listeria monocytogenes isolates linked to fatal outcomes in elderly patients with cancer. In addition, listeriosis patients with cancer present low IL-17A/IL-6 ratios and significantly reduced levels of anti-GAPDH1-22 antibodies, identified as two novel biomarkers of poor prognosis. Analysis of these biomarkers may aid in reducing the incidence of listeriosis. Moreover, GAPDH1-22-activated monocyte-derived dendritic cells of listeriosis patients with cancer seem useful tools to prepare clinical vaccines as they produce mainly Th1 cytokines.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 14%
Student > Doctoral Student 3 14%
Student > Bachelor 2 10%
Student > Ph. D. Student 2 10%
Other 1 5%
Other 4 19%
Unknown 6 29%
Readers by discipline Count As %
Immunology and Microbiology 4 19%
Agricultural and Biological Sciences 4 19%
Nursing and Health Professions 2 10%
Environmental Science 1 5%
Unspecified 1 5%
Other 3 14%
Unknown 6 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2016.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from Frontiers in immunology
#27,414
of 31,513 outputs
Outputs of similar age
#356,953
of 416,861 outputs
Outputs of similar age from Frontiers in immunology
#232
of 250 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,513 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 250 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.