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IFN-λ: A New Inducer of Local Immunity against Cancer and Infections

Overview of attention for article published in Frontiers in immunology, December 2016
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Title
IFN-λ: A New Inducer of Local Immunity against Cancer and Infections
Published in
Frontiers in immunology, December 2016
DOI 10.3389/fimmu.2016.00598
Pubmed ID
Authors

Ahmed Lasfar, Andrew Zloza, Andrew de la Torre, Karine A. Cohen-Solal

Abstract

IFN-λ is the newly established type III IFN with unique immunomodulatory functions. In contrast to the IFN-α/β family and to some extent IFN-γ, IFN-λ is apparently acting in specific areas of the body to activate resident immune cells and induces a local immunity, instrumental in preventing particular infections and also keeping transformed cells under control. Mucosal areas of lung and gastrointestinal tracts are now under scrutiny to elucidate the immune mechanisms triggered by IFN-λ and leading to viral protection. New evidence also indicates the crucial role of IFN-λ in promoting innate immunity in solid cancer models. Based on its unique biological activities among the IFN system, new immunotherapeutic approaches are now emerging for the treatment of cancer, infection, and autoimmune diseases. In the present review, we highlight the recent advances of IFN-λ immunomodulatory functions. We also discuss the perspectives of IFN-λ as a therapeutic agent.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 2%
Unknown 44 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 20%
Student > Ph. D. Student 8 18%
Student > Doctoral Student 6 13%
Student > Master 5 11%
Student > Bachelor 3 7%
Other 1 2%
Unknown 13 29%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 24%
Agricultural and Biological Sciences 11 24%
Immunology and Microbiology 5 11%
Medicine and Dentistry 4 9%
Veterinary Science and Veterinary Medicine 1 2%
Other 2 4%
Unknown 11 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2016.
All research outputs
#15,740,505
of 25,374,917 outputs
Outputs from Frontiers in immunology
#15,380
of 31,520 outputs
Outputs of similar age
#235,721
of 421,155 outputs
Outputs of similar age from Frontiers in immunology
#162
of 270 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,520 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,155 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 270 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.