Title |
IFN-λ: A New Inducer of Local Immunity against Cancer and Infections
|
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Published in |
Frontiers in immunology, December 2016
|
DOI | 10.3389/fimmu.2016.00598 |
Pubmed ID | |
Authors |
Ahmed Lasfar, Andrew Zloza, Andrew de la Torre, Karine A. Cohen-Solal |
Abstract |
IFN-λ is the newly established type III IFN with unique immunomodulatory functions. In contrast to the IFN-α/β family and to some extent IFN-γ, IFN-λ is apparently acting in specific areas of the body to activate resident immune cells and induces a local immunity, instrumental in preventing particular infections and also keeping transformed cells under control. Mucosal areas of lung and gastrointestinal tracts are now under scrutiny to elucidate the immune mechanisms triggered by IFN-λ and leading to viral protection. New evidence also indicates the crucial role of IFN-λ in promoting innate immunity in solid cancer models. Based on its unique biological activities among the IFN system, new immunotherapeutic approaches are now emerging for the treatment of cancer, infection, and autoimmune diseases. In the present review, we highlight the recent advances of IFN-λ immunomodulatory functions. We also discuss the perspectives of IFN-λ as a therapeutic agent. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
Switzerland | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 2% |
Unknown | 44 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 20% |
Student > Ph. D. Student | 8 | 18% |
Student > Doctoral Student | 6 | 13% |
Student > Master | 5 | 11% |
Student > Bachelor | 3 | 7% |
Other | 1 | 2% |
Unknown | 13 | 29% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 11 | 24% |
Agricultural and Biological Sciences | 11 | 24% |
Immunology and Microbiology | 5 | 11% |
Medicine and Dentistry | 4 | 9% |
Veterinary Science and Veterinary Medicine | 1 | 2% |
Other | 2 | 4% |
Unknown | 11 | 24% |