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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Effects of Interferons and Viruses on Metabolism
|
|---|---|
| Published in |
Frontiers in immunology, January 2016
|
| DOI | 10.3389/fimmu.2016.00630 |
| Pubmed ID | |
| Authors |
Stephanie Deborah Fritsch, Thomas Weichhart |
| Abstract |
Interferons (IFNs) are potent pleiotropic cytokines that broadly alter cellular functions in response to viral and other infections. These alterations include changes in protein synthesis, proliferation, membrane composition, and the nutritional microenvironment. Recent evidence suggests that antiviral responses are supported by an IFN-induced rewiring of the cellular metabolism. In this review, we discuss the roles of type I and type II IFNs in regulating the cellular metabolism and biosynthetic reactions. Furthermore, we give an overview of how viruses themselves affect these metabolic activities to promote their replication. In addition, we focus on the lipid as well as amino acid metabolisms, through which IFNs exert potent antiviral and immunomodulatory activities. Conversely, the expression of IFNs is controlled by the nutrient sensor mammalian target of rapamycin or by direct reprograming of lipid metabolic pathways. These findings establish a mutual relationship between IFN production and metabolic core processes. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 13% |
| Switzerland | 1 | 13% |
| Unknown | 6 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 50% |
| Practitioners (doctors, other healthcare professionals) | 3 | 38% |
| Scientists | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 173 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 172 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 16% |
| Researcher | 24 | 14% |
| Student > Master | 24 | 14% |
| Student > Bachelor | 19 | 11% |
| Student > Doctoral Student | 12 | 7% |
| Other | 24 | 14% |
| Unknown | 43 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 39 | 23% |
| Immunology and Microbiology | 38 | 22% |
| Agricultural and Biological Sciences | 26 | 15% |
| Medicine and Dentistry | 7 | 4% |
| Neuroscience | 3 | 2% |
| Other | 17 | 10% |
| Unknown | 43 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2020.
All research outputs
#2,686,848
of 25,703,943 outputs
Outputs from Frontiers in immunology
#2,750
of 32,216 outputs
Outputs of similar age
#43,513
of 401,595 outputs
Outputs of similar age from Frontiers in immunology
#15
of 135 outputs
Altmetric has tracked 25,703,943 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 32,216 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 401,595 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 135 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.