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Mendeley readers
Attention Score in Context
| Title |
Lysosome-Dependent Activation of Human Dendritic Cells by the Vaccine Adjuvant QS-21
|
|---|---|
| Published in |
Frontiers in immunology, January 2017
|
| DOI | 10.3389/fimmu.2016.00663 |
| Pubmed ID | |
| Authors |
Iain Welsby, Sophie Detienne, Francisca N’Kuli, Séverine Thomas, Sandrine Wouters, Viviane Bechtold, Dominique De Wit, Romain Gineste, Thomas Reinheckel, Abdelatif Elouahabi, Pierre J. Courtoy, Arnaud M. Didierlaurent, Stanislas Goriely |
| Abstract |
The adjuvant properties of the saponin QS-21 have been known for decades. It is a component of the Adjuvant System AS01 that is used in several vaccine candidates. QS-21 strongly potentiates both cellular and humoral immune responses to purified antigens, yet how it activates immune cells is largely unknown. Here, we report that QS-21 directly activated human monocyte-derived dendritic cells (moDCs) and promoted a pro-inflammatory transcriptional program. Cholesterol-dependent QS-21 endocytosis followed by lysosomal destabilization and Syk kinase activation were prerequisites for this response. Cathepsin B, a lysosomal cysteine protease, was essential for moDC activation in vitro and contributed to the adjuvant effects of QS-21 in vivo. Collectively, these findings provide new insights into the pathways involved in the direct activation of antigen-presenting cells by a clinically relevant QS-21 formulation. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 88 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 25% |
| Researcher | 9 | 10% |
| Student > Bachelor | 8 | 9% |
| Professor | 6 | 7% |
| Student > Master | 6 | 7% |
| Other | 14 | 16% |
| Unknown | 23 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 22 | 25% |
| Agricultural and Biological Sciences | 11 | 13% |
| Biochemistry, Genetics and Molecular Biology | 9 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 7% |
| Medicine and Dentistry | 5 | 6% |
| Other | 9 | 10% |
| Unknown | 26 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2018.
All research outputs
#4,552,557
of 25,394,764 outputs
Outputs from Frontiers in immunology
#4,864
of 31,554 outputs
Outputs of similar age
#81,918
of 421,841 outputs
Outputs of similar age from Frontiers in immunology
#47
of 343 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,554 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,841 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 343 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.