Title |
Pro-inflammatory-Related Loss of CXCL12 Niche Promotes Acute Lymphoblastic Leukemic Progression at the Expense of Normal Lymphopoiesis
|
---|---|
Published in |
Frontiers in immunology, January 2017
|
DOI | 10.3389/fimmu.2016.00666 |
Pubmed ID | |
Authors |
Juan Carlos Balandrán, Jessica Purizaca, Jennifer Enciso, David Dozal, Antonio Sandoval, Elva Jiménez-Hernández, Leticia Alemán-Lazarini, Vadim Perez-Koldenkova, Henry Quintela-Núñez del Prado, Jussara Rios de los Ríos, Héctor Mayani, Vianney Ortiz-Navarrete, Monica L. Guzman, Rosana Pelayo |
Abstract |
Pediatric oncology, notably childhood acute lymphoblastic leukemia (ALL), is currently one of the health-leading concerns worldwide and a biomedical priority. Decreasing overall leukemia mortality in children requires a comprehensive understanding of its pathobiology. It is becoming clear that malignant cell-to-niche intercommunication and microenvironmental signals that control early cell fate decisions are critical for tumor progression. We show here that the mesenchymal stromal cell component of ALL bone marrow (BM) differ from its normal counterpart in a number of functional properties and may have a key role during leukemic development. A decreased proliferation potential, contrasting with the strong ability of producing pro-inflammatory cytokines and an aberrantly loss of CXCL12 and SCF, suggest that leukemic lymphoid niches in ALL BM are unique and may exclude normal hematopoiesis. Cell competence ex vivo assays within tridimensional coculture structures indicated a growth advantage of leukemic precursor cells and their niche remodeling ability by CXCL12 reduction, resulting in leukemic cell progression at the expense of normal niche-associated lymphopoiesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 17% |
Switzerland | 1 | 17% |
Unknown | 4 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 50% |
Practitioners (doctors, other healthcare professionals) | 2 | 33% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 82 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 17% |
Student > Bachelor | 12 | 15% |
Student > Master | 11 | 13% |
Student > Doctoral Student | 7 | 9% |
Researcher | 7 | 9% |
Other | 9 | 11% |
Unknown | 22 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 18 | 22% |
Agricultural and Biological Sciences | 11 | 13% |
Medicine and Dentistry | 11 | 13% |
Immunology and Microbiology | 10 | 12% |
Business, Management and Accounting | 2 | 2% |
Other | 5 | 6% |
Unknown | 25 | 30% |