Title |
NETopathies? Unraveling the Dark Side of Old Diseases through Neutrophils
|
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Published in |
Frontiers in immunology, January 2017
|
DOI | 10.3389/fimmu.2016.00678 |
Pubmed ID | |
Authors |
Alexandros Mitsios, Athanasios Arampatzioglou, Stella Arelaki, Ioannis Mitroulis, Konstantinos Ritis |
Abstract |
Neutrophil extracellular traps (NETs) were initially described as an antimicrobial mechanism of neutrophils. Over the last decade, several lines of evidence support the involvement of NETs in a plethora of pathological conditions. Clinical and experimental data indicate that NET release constitutes a shared mechanism, which is involved in a different degree in various manifestations of non-infectious diseases. Even though the backbone of NETs is similar, there are differences in their protein load in different diseases, which represent alterations in neutrophil protein expression in distinct disorder-specific microenvironments. The characterization of NET protein load in different NET-driven disorders could be of significant diagnostic and/or therapeutic value. Additionally, it will provide further evidence for the role of NETs in disease pathogenesis, and it will enable the characterization of disorders in which neutrophils and NET-dependent inflammation are of critical importance. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Poland | 1 | <1% |
Unknown | 106 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 18 | 17% |
Student > Ph. D. Student | 16 | 15% |
Other | 11 | 10% |
Student > Bachelor | 11 | 10% |
Student > Master | 8 | 7% |
Other | 19 | 18% |
Unknown | 24 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 23 | 21% |
Biochemistry, Genetics and Molecular Biology | 18 | 17% |
Medicine and Dentistry | 16 | 15% |
Agricultural and Biological Sciences | 12 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Other | 7 | 7% |
Unknown | 28 | 26% |