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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Intestinal Microbiota-Derived GABA Mediates Interleukin-17 Expression during Enterotoxigenic Escherichia coli Infection
|
|---|---|
| Published in |
Frontiers in immunology, January 2017
|
| DOI | 10.3389/fimmu.2016.00685 |
| Pubmed ID | |
| Authors |
Wenkai Ren, Jie Yin, Hao Xiao, Shuai Chen, Gang Liu, Bie Tan, Nengzhang Li, Yuanyi Peng, Tiejun Li, Benhua Zeng, Wenxia Li, Hong Wei, Zhinan Yin, Guoyao Wu, Philip R. Hardwidge, Yulong Yin |
| Abstract |
Intestinal microbiota has critical importance in pathogenesis of intestinal infection; however, the role of intestinal microbiota in intestinal immunity during enterotoxigenic Escherichia coli (ETEC) infection is poorly understood. The present study tested the hypothesis that the intestinal microbiota is associated with intestinal interleukin-17 (IL-17) expression in response to ETEC infection. Here, we found ETEC infection induced expression of intestinal IL-17 and dysbiosis of intestinal microbiota, increasing abundance of γ-aminobutyric acid (GABA)-producing Lactococcus lactis subsp. lactis. Antibiotics treatment in mice lowered the expression of intestinal IL-17 during ETEC infection, while GABA or L. lactis subsp. lactis administration restored the expression of intestinal IL-17. L. lactis subsp. lactis administration also promoted expression of intestinal IL-17 in germ-free mice during ETEC infection. GABA enhanced intestinal IL-17 expression in the context of ETEC infection through activating mechanistic target of rapamycin complex 1 (mTORC1)-ribosomal protein S6 kinase 1 (S6K1) signaling. GABA-mTORC1 signaling also affected intestinal IL-17 expression in response to Citrobacter rodentium infection and in drug-induced model of intestinal inflammation. These findings highlight the importance of intestinal GABA signaling in intestinal IL-17 expression during intestinal infection and indicate the potential of intestinal microbiota-GABA signaling in IL-17-associated intestinal diseases. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 20% |
| Switzerland | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 54 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 10 | 19% |
| Student > Master | 9 | 17% |
| Researcher | 8 | 15% |
| Student > Ph. D. Student | 7 | 13% |
| Lecturer | 2 | 4% |
| Other | 8 | 15% |
| Unknown | 10 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 19% |
| Immunology and Microbiology | 7 | 13% |
| Biochemistry, Genetics and Molecular Biology | 6 | 11% |
| Veterinary Science and Veterinary Medicine | 5 | 9% |
| Medicine and Dentistry | 5 | 9% |
| Other | 7 | 13% |
| Unknown | 14 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2022.
All research outputs
#3,138,701
of 25,374,647 outputs
Outputs from Frontiers in immunology
#3,309
of 31,520 outputs
Outputs of similar age
#59,983
of 422,202 outputs
Outputs of similar age from Frontiers in immunology
#38
of 357 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,520 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 422,202 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 357 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.