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X Demographics
Mendeley readers
Attention Score in Context
| Title |
STATs in NK-Cells: The Good, the Bad, and the Ugly
|
|---|---|
| Published in |
Frontiers in immunology, January 2017
|
| DOI | 10.3389/fimmu.2016.00694 |
| Pubmed ID | |
| Authors |
Dagmar Gotthardt, Veronika Sexl |
| Abstract |
Natural killer (NK)-cells are major players in the fight against viral infections and transformed cells, but there is increasing evidence attributing a disease-promoting role to NK-cells. Cytokines present in the tumor microenvironment shape NK-cell maturation, function, and effector responses. Many cytokines signal via the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway that is also frequently altered and constitutively active in a broad range of tumor cells. As a consequence, there are currently major efforts to develop therapeutic strategies to target this pathway. Therefore, it is of utmost importance to understand the role and contributions of JAK-STAT molecules in NK-cell biology-only this knowledge will allow us to predict effects of JAK-STAT inhibition for NK-cell functions and to successfully apply precision medicine. We will review the current knowledge on the role of JAK-STAT signaling for NK-cell functions and discuss conditions involved in the switch from NK-cell tumor surveillance to disease promotion. |
X Demographics
The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 14% |
| Venezuela, Bolivarian Republic of | 2 | 9% |
| Mexico | 2 | 9% |
| Canada | 1 | 5% |
| Malaysia | 1 | 5% |
| Singapore | 1 | 5% |
| Russia | 1 | 5% |
| Austria | 1 | 5% |
| Unknown | 10 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 64% |
| Scientists | 8 | 36% |
Mendeley readers
The data shown below were compiled from readership statistics for 128 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| Germany | 1 | <1% |
| France | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 124 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 17% |
| Student > Master | 20 | 16% |
| Researcher | 19 | 15% |
| Student > Bachelor | 13 | 10% |
| Student > Doctoral Student | 10 | 8% |
| Other | 9 | 7% |
| Unknown | 35 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 30 | 23% |
| Biochemistry, Genetics and Molecular Biology | 23 | 18% |
| Agricultural and Biological Sciences | 14 | 11% |
| Medicine and Dentistry | 10 | 8% |
| Engineering | 2 | 2% |
| Other | 7 | 5% |
| Unknown | 42 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2020.
All research outputs
#2,403,737
of 25,394,764 outputs
Outputs from Frontiers in immunology
#2,344
of 31,554 outputs
Outputs of similar age
#47,508
of 421,548 outputs
Outputs of similar age from Frontiers in immunology
#27
of 361 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,554 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,548 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 361 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.