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CD28− and CD28lowCD8+ Regulatory T Cells: Of Mice and Men

Overview of attention for article published in Frontiers in immunology, January 2017
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Title
CD28− and CD28lowCD8+ Regulatory T Cells: Of Mice and Men
Published in
Frontiers in immunology, January 2017
DOI 10.3389/fimmu.2017.00031
Pubmed ID
Authors

Yirajen Vuddamalay, Joost P. M. van Meerwijk

Abstract

Since the rebirth of regulatory (formerly known as suppressor) T cells in the early 1990s, research in the field of immune-regulation by various T cell populations has quickly gained momentum. While T cells expressing the transcription factor Foxp3 are currently in the spotlight, several other T cell populations endowed with potent immunomodulatory capacities have been identified in both the CD8(+) and CD4(+) compartment. The fundamental difference between CD4(+) and CD8(+) T cells in terms of antigen recognition suggests non-redundant, and perhaps complementary, functions of regulatory CD4(+) and CD8(+) T cells in immunoregulation. This emphasizes the importance and necessity of continuous research on both subpopulations of regulatory T cells (Tregs) so as to decipher their complex physiological relevance and possible synergy. Two distinct CD8-expressing Treg populations can be distinguished based on expression of the co-stimulatory receptor CD28. Here, we review the literature on these (at least in part) thymus-derived CD28(low) and peripherally induced CD28(-)CD8(+) Tregs.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Other 10 23%
Student > Ph. D. Student 10 23%
Student > Bachelor 4 9%
Student > Master 4 9%
Researcher 4 9%
Other 5 11%
Unknown 7 16%
Readers by discipline Count As %
Immunology and Microbiology 12 27%
Medicine and Dentistry 10 23%
Agricultural and Biological Sciences 6 14%
Biochemistry, Genetics and Molecular Biology 4 9%
Chemical Engineering 1 2%
Other 2 5%
Unknown 9 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2017.
All research outputs
#19,947,956
of 25,377,790 outputs
Outputs from Frontiers in immunology
#22,585
of 31,531 outputs
Outputs of similar age
#305,176
of 422,539 outputs
Outputs of similar age from Frontiers in immunology
#285
of 373 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,531 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 422,539 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 373 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.