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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Canonical and Non-Canonical Activation of NLRP3 Inflammasome at the Crossroad between Immune Tolerance and Intestinal Inflammation
|
|---|---|
| Published in |
Frontiers in immunology, January 2017
|
| DOI | 10.3389/fimmu.2017.00036 |
| Pubmed ID | |
| Authors |
Carolina Pellegrini, Luca Antonioli, Gloria Lopez-Castejon, Corrado Blandizzi, Matteo Fornai |
| Abstract |
Several lines of evidence point out the relevance of nucleotide-binding oligomerization domain leucine rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome as a pivotal player in regulating the integrity of intestinal homeostasis and shaping innate immune responses during bowel inflammation. Intensive research efforts are being made to achieve an integrated view about the protective/detrimental role of canonical and non-canonical NLRP3 inflammasome activation in the maintenance of intestinal microenvironment integrity. Evidence is also emerging that the pharmacological modulation of NLRP3 inflammasome could represent a promising molecular target for the therapeutic management of inflammatory immune-mediated gut diseases. The present review has been intended to provide a critical appraisal of the available knowledge about the role of canonical and non-canonical NLRP3 inflammasome activation in the dynamic interplay between microbiota, intestinal epithelium, and innate immune system, taken together as a whole integrated network regulating the maintenance/breakdown of intestinal homeostasis. Moreover, special attention has been paid to the pharmacological modulation of NLRP3 inflammasome, emphasizing the concept that this multiprotein complex could represent a suitable target for the management of inflammatory bowel diseases. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 11% |
| Australia | 1 | 11% |
| Canada | 1 | 11% |
| Spain | 1 | 11% |
| Switzerland | 1 | 11% |
| Unknown | 4 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 89% |
| Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 224 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 224 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 42 | 19% |
| Student > Master | 31 | 14% |
| Researcher | 28 | 13% |
| Student > Bachelor | 27 | 12% |
| Student > Doctoral Student | 12 | 5% |
| Other | 25 | 11% |
| Unknown | 59 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 41 | 18% |
| Agricultural and Biological Sciences | 33 | 15% |
| Biochemistry, Genetics and Molecular Biology | 31 | 14% |
| Medicine and Dentistry | 16 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 13 | 6% |
| Other | 27 | 12% |
| Unknown | 63 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2020.
All research outputs
#7,150,392
of 25,377,790 outputs
Outputs from Frontiers in immunology
#7,980
of 31,531 outputs
Outputs of similar age
#124,089
of 422,427 outputs
Outputs of similar age from Frontiers in immunology
#106
of 372 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 31,531 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 422,427 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 372 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.