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Mendeley readers
Attention Score in Context
| Title |
FHL2 Regulates Natural Killer Cell Development and Activation during Streptococcus pneumoniae Infection
|
|---|---|
| Published in |
Frontiers in immunology, February 2017
|
| DOI | 10.3389/fimmu.2017.00123 |
| Pubmed ID | |
| Authors |
Thomas Baranek, Eric Morello, Alexandre Valayer, Rose-France Aimar, Déborah Bréa, Clemence Henry, Anne-Gaelle Besnard, Emilie Dalloneau, Antoine Guillon, Pierre-François Dequin, Emilie Narni-Mancinelli, Eric Vivier, Fabrice Laurent, Yu Wei, Christophe Paget, Mustapha Si-Tahar |
| Abstract |
Recent in silico studies suggested that the transcription cofactor LIM-only protein FHL2 is a major transcriptional regulator of mouse natural killer (NK) cells. However, the expression and role of FHL2 in NK cell biology are unknown. Here, we confirm that FHL2 is expressed in both mouse and human NK cells. Using FHL2(-/-) mice, we found that FHL2 controls NK cell development in the bone marrow and maturation in peripheral organs. To evaluate the importance of FHL2 in NK cell activation, FHL2(-/-) mice were infected with Streptococcus pneumoniae. FHL2(-/-) mice are highly susceptible to this infection. The activation of lung NK cells is altered in FHL2(-/-) mice, leading to decreased IFNγ production and a loss of control of bacterial burden. Collectively, our data reveal that FHL2 is a new transcription cofactor implicated in NK cell development and activation during pulmonary bacterial infection. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 3 | 60% |
| Switzerland | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 5% |
| Unknown | 19 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 35% |
| Student > Ph. D. Student | 4 | 20% |
| Other | 2 | 10% |
| Professor | 1 | 5% |
| Student > Master | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 4 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 7 | 35% |
| Agricultural and Biological Sciences | 6 | 30% |
| Biochemistry, Genetics and Molecular Biology | 2 | 10% |
| Medicine and Dentistry | 1 | 5% |
| Unknown | 4 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2017.
All research outputs
#15,173,117
of 25,382,440 outputs
Outputs from Frontiers in immunology
#14,217
of 31,531 outputs
Outputs of similar age
#228,674
of 431,921 outputs
Outputs of similar age from Frontiers in immunology
#224
of 397 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,531 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 431,921 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 397 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.