You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
TLR7 Deficiency Leads to TLR8 Compensative Regulation of Immune Response against JEV in Mice
|
|---|---|
| Published in |
Frontiers in immunology, February 2017
|
| DOI | 10.3389/fimmu.2017.00160 |
| Pubmed ID | |
| Authors |
Muhammad Awais, Ke Wang, Xianwu Lin, Wenjie Qian, Nan Zhang, Chong Wang, Kunlun Wang, Ling Zhao, Zhen F. Fu, Min Cui |
| Abstract |
Japanese encephalitis virus (JEV) is a highly fatal pathogen to human beings. Toll-like receptor 7 (TLR7) plays a role as the first host defense against most single-stranded RNA flaviviruses. This study aims to investigate the role of TLR7 in inducing adaptive immune response in mice against JEV. In vitro and in vivo studies were conducted to examine the expression of toll-like receptors (TLRs) in mice. After JEV infection, physical parameters of mice (survival rate and body weight) were evaluated, and organs or cells were collected for further analysis. The expression of TLR7 was increased significantly as compare to other TLR molecules post-JEV infection. The expression of CD80, CD86, and CD273 on bone marrow-derived dendritic cells was increased significantly in TLR7(-/-) mice. Furthermore, viral load was also increased significantly in TLR7(-/-) mice as compare to C57BL/6 mice. But there was no significant difference among survival rate and body weight in TLR7(-/-) mice as compare to C57BL/6. Interestingly, we also found that TLR8 was upregulated in TLR7(-/-) mice. The study concluded that TLR8 was upregulated in TLR7-deficient mice, and it might play a compensatory role in the immune response in TLR7(-/-) mice. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 32 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 19% |
| Researcher | 4 | 13% |
| Student > Doctoral Student | 2 | 6% |
| Student > Ph. D. Student | 2 | 6% |
| Student > Master | 2 | 6% |
| Other | 4 | 13% |
| Unknown | 12 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 4 | 13% |
| Biochemistry, Genetics and Molecular Biology | 4 | 13% |
| Medicine and Dentistry | 3 | 9% |
| Agricultural and Biological Sciences | 3 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Other | 6 | 19% |
| Unknown | 11 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2023.
All research outputs
#8,264,793
of 25,382,440 outputs
Outputs from Frontiers in immunology
#10,116
of 31,531 outputs
Outputs of similar age
#124,152
of 323,273 outputs
Outputs of similar age from Frontiers in immunology
#173
of 421 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 31,531 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,273 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 421 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.