Title |
Lanthionine Synthetase C-Like 2 Modulates Immune Responses to Influenza Virus Infection
|
---|---|
Published in |
Frontiers in immunology, February 2017
|
DOI | 10.3389/fimmu.2017.00178 |
Pubmed ID | |
Authors |
Andrew Leber, Josep Bassaganya-Riera, Nuria Tubau-Juni, Victoria Zoccoli-Rodriguez, Pinyi Lu, Victoria Godfrey, Shiv Kale, Raquel Hontecillas |
Abstract |
Broad-based, host-targeted therapeutics have the potential to ameliorate viral infections without inducing antiviral resistance. We identified lanthionine synthetase C-like 2 (LANCL2) as a new therapeutic target for immunoinflammatory diseases. To examine the therapeutic efficacy of oral NSC61610 administration on influenza, we infected C57BL/6 mice with influenza A H1N1pdm virus and evaluated influenza-related mortality, lung inflammatory profiles, and pulmonary histopathology. Oral treatment with NSC61610 ameliorates influenza virus infection by down-modulating pulmonary inflammation through the downregulation of TNF-α and MCP-1 and reduction in the infiltration of neutrophils. NSC61610 treatment increases IL10-producing CD8+ T cells and macrophages in the lungs during the resolution phase of disease. The loss of LANCL2 or neutralization of IL-10 in mice infected with influenza virus abrogates the ability of NSC61610 to accelerate recovery and induce IL-10-mediated regulatory responses. These studies validate that oral treatment with NSC61610 ameliorates morbidity and mortality and accelerates recovery during influenza virus infection through a mechanism mediated by activation of LANCL2 and subsequent induction of IL-10 responses by CD8+ T cells and macrophages in the lungs. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 67% |
Switzerland | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 42% |
Researcher | 2 | 11% |
Student > Master | 2 | 11% |
Professor | 1 | 5% |
Unspecified | 1 | 5% |
Other | 2 | 11% |
Unknown | 3 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 3 | 16% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 11% |
Biochemistry, Genetics and Molecular Biology | 2 | 11% |
Medicine and Dentistry | 2 | 11% |
Nursing and Health Professions | 1 | 5% |
Other | 4 | 21% |
Unknown | 5 | 26% |