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Lifetime Modulation of the Pain System via Neuroimmune and Neuroendocrine Interactions

Overview of attention for article published in Frontiers in immunology, March 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

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21 X users
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1 Facebook page

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94 Mendeley
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Title
Lifetime Modulation of the Pain System via Neuroimmune and Neuroendocrine Interactions
Published in
Frontiers in immunology, March 2017
DOI 10.3389/fimmu.2017.00276
Pubmed ID
Authors

Ihssane Zouikr, Bianka Karshikoff

Abstract

Chronic pain is a debilitating condition that still is challenging both clinicians and researchers. Despite intense research, it is still not clear why some individuals develop chronic pain while others do not or how to heal this disease. In this review, we argue for a multisystem approach to understand chronic pain. Pain is not only to be viewed simply as a result of aberrant neuronal activity but also as a result of adverse early-life experiences that impact an individual's endocrine, immune, and nervous systems and changes which in turn program the pain system. First, we give an overview of the ontogeny of the central nervous system, endocrine, and immune systems and their windows of vulnerability. Thereafter, we summarize human and animal findings from our laboratories and others that point to an important role of the endocrine and immune systems in modulating pain sensitivity. Taking "early-life history" into account, together with the past and current immunological and endocrine status of chronic pain patients, is a necessary step to understand chronic pain pathophysiology and assist clinicians in tailoring the best therapeutic approach.

X Demographics

X Demographics

The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Israel 1 1%
Unknown 93 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 18%
Student > Master 12 13%
Student > Ph. D. Student 11 12%
Student > Doctoral Student 8 9%
Professor > Associate Professor 7 7%
Other 19 20%
Unknown 20 21%
Readers by discipline Count As %
Medicine and Dentistry 24 26%
Neuroscience 18 19%
Nursing and Health Professions 8 9%
Agricultural and Biological Sciences 5 5%
Biochemistry, Genetics and Molecular Biology 5 5%
Other 12 13%
Unknown 22 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2020.
All research outputs
#2,783,405
of 25,382,440 outputs
Outputs from Frontiers in immunology
#2,857
of 31,531 outputs
Outputs of similar age
#50,715
of 322,532 outputs
Outputs of similar age from Frontiers in immunology
#48
of 446 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,531 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,532 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 446 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.