Title |
Natural Killers Are Made Not Born: How to Exploit NK Cells in Lung Malignancies
|
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Published in |
Frontiers in immunology, March 2017
|
DOI | 10.3389/fimmu.2017.00277 |
Pubmed ID | |
Authors |
Paolo Carrega, Guido Ferlazzo |
Abstract |
In recent years, progress has been made in the characterization of natural killer (NK) cells in lung malignancies, and we have now gained a better understanding of the frequency, localization, phenotype, and functional status of NK cells infiltrating these tumors. NK cell subset recruited in lung cancer is mainly capable of producing relevant cytokines rather than exerting direct cancer cell killing. Thus, the relevance of NK cells in tumor microenvironment might also go beyond the killing of tumor cells, being NK cells endowed with regulatory functions toward an ample array of immune effectors. Nevertheless, boosting their cytotoxic functions and redirecting the migration of cytotoxic NK cell subset to the tumor site might open new therapeutic avenues for lung cancer. Also, we believe that a deeper investigation into the impact of both conventional (e.g., chemotherapy) or new therapies (e.g., anti-immune checkpoints mAbs) on NK cell homeostasis in lung cancer patients is now required. |
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Geographical breakdown
Country | Count | As % |
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United States | 2 | 20% |
Switzerland | 1 | 10% |
Unknown | 7 | 70% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 60% |
Scientists | 4 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 2% |
Unknown | 45 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 20% |
Other | 6 | 13% |
Researcher | 6 | 13% |
Student > Master | 4 | 9% |
Student > Bachelor | 3 | 7% |
Other | 3 | 7% |
Unknown | 15 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 10 | 22% |
Biochemistry, Genetics and Molecular Biology | 8 | 17% |
Agricultural and Biological Sciences | 5 | 11% |
Engineering | 2 | 4% |
Medicine and Dentistry | 2 | 4% |
Other | 3 | 7% |
Unknown | 16 | 35% |