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Natural Killers Are Made Not Born: How to Exploit NK Cells in Lung Malignancies

Overview of attention for article published in Frontiers in immunology, March 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

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Title
Natural Killers Are Made Not Born: How to Exploit NK Cells in Lung Malignancies
Published in
Frontiers in immunology, March 2017
DOI 10.3389/fimmu.2017.00277
Pubmed ID
Authors

Paolo Carrega, Guido Ferlazzo

Abstract

In recent years, progress has been made in the characterization of natural killer (NK) cells in lung malignancies, and we have now gained a better understanding of the frequency, localization, phenotype, and functional status of NK cells infiltrating these tumors. NK cell subset recruited in lung cancer is mainly capable of producing relevant cytokines rather than exerting direct cancer cell killing. Thus, the relevance of NK cells in tumor microenvironment might also go beyond the killing of tumor cells, being NK cells endowed with regulatory functions toward an ample array of immune effectors. Nevertheless, boosting their cytotoxic functions and redirecting the migration of cytotoxic NK cell subset to the tumor site might open new therapeutic avenues for lung cancer. Also, we believe that a deeper investigation into the impact of both conventional (e.g., chemotherapy) or new therapies (e.g., anti-immune checkpoints mAbs) on NK cell homeostasis in lung cancer patients is now required.

X Demographics

X Demographics

The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Unknown 45 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 20%
Other 6 13%
Researcher 6 13%
Student > Master 4 9%
Student > Bachelor 3 7%
Other 3 7%
Unknown 15 33%
Readers by discipline Count As %
Immunology and Microbiology 10 22%
Biochemistry, Genetics and Molecular Biology 8 17%
Agricultural and Biological Sciences 5 11%
Engineering 2 4%
Medicine and Dentistry 2 4%
Other 3 7%
Unknown 16 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 March 2017.
All research outputs
#6,267,478
of 25,382,440 outputs
Outputs from Frontiers in immunology
#6,373
of 31,531 outputs
Outputs of similar age
#93,768
of 322,532 outputs
Outputs of similar age from Frontiers in immunology
#109
of 446 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,531 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,532 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 446 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.