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X Demographics
Mendeley readers
Attention Score in Context
| Title |
CD16+ Monocytes and Skewed Macrophage Polarization toward M2 Type Hallmark Heart Transplant Acute Cellular Rejection
|
|---|---|
| Published in |
Frontiers in immunology, March 2017
|
| DOI | 10.3389/fimmu.2017.00346 |
| Pubmed ID | |
| Authors |
Thierry P. P. van den Bosch, Kadir Caliskan, Marina D. Kraaij, Alina A. Constantinescu, Olivier C. Manintveld, Pieter J. M. Leenen, Jan H. von der Thüsen, Marian C. Clahsen-van Groningen, Carla C. Baan, Ajda T. Rowshani |
| Abstract |
During acute heart transplant rejection, infiltration of lymphocytes and monocytes is followed by endothelial injury and eventually myocardial fibrosis. To date, no information is available on monocyte-macrophage-related cellular shifts and their polarization status during rejection. Here, we aimed to define and correlate monocyte-macrophage endomyocardial tissue profiles obtained at rejection and time points prior to rejection, with corresponding serial blood samples in 25 heart transplant recipients experiencing acute cellular rejection. Additionally, 33 healthy individuals served as control. Using histology, immunohistochemistry, confocal laser scan microscopy, and digital imaging expression of CD14, CD16, CD56, CD68, CD80, and CD163 were explored to define monocyte and macrophage tissue profiles during rejection. Fibrosis was investigated using Sirius Red stainings of rejection, non-rejection, and 1-year biopsies. Expression of co-stimulatory and migration-related molecules on circulating monocytes, and production potential for pro- and anti-inflammatory cytokines were studied using flow cytometry. At tissue level, striking CD16+ monocyte infiltration was observed during rejection (p < 0.001). Significantly more CD68+CD163+ M2 macrophages were documented during rejection compared to barely present CD68+CD80+ M1 macrophages. Rejection was associated with severe fibrosis in 1-year biopsies (p < 0.001). Irrespective of rejection status, decreased frequencies of circulating CD16+ monocytes were found in patients compared to healthy individuals. Rejection was reflected by significantly increased CD54 and HLA-DR expression on CD16+ monocytes with retained cytokine production potential. CD16+ monocytes and M2 macrophages hallmark the correlates of heart transplant acute cellular rejection on tissue level and seem to be associated with fibrosis in the long term. |
X Demographics
The data shown below were collected from the profiles of 52 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 15 | 29% |
| United Kingdom | 2 | 4% |
| Canada | 2 | 4% |
| India | 2 | 4% |
| Korea, Republic of | 1 | 2% |
| France | 1 | 2% |
| Argentina | 1 | 2% |
| Australia | 1 | 2% |
| Mexico | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 25 | 48% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 47 | 90% |
| Practitioners (doctors, other healthcare professionals) | 4 | 8% |
| Scientists | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 53 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 23% |
| Researcher | 10 | 19% |
| Student > Bachelor | 6 | 11% |
| Professor > Associate Professor | 5 | 9% |
| Student > Doctoral Student | 4 | 8% |
| Other | 6 | 11% |
| Unknown | 10 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 30% |
| Biochemistry, Genetics and Molecular Biology | 9 | 17% |
| Immunology and Microbiology | 7 | 13% |
| Agricultural and Biological Sciences | 3 | 6% |
| Mathematics | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 15 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2022.
All research outputs
#1,350,504
of 25,806,763 outputs
Outputs from Frontiers in immunology
#1,185
of 32,415 outputs
Outputs of similar age
#26,012
of 324,009 outputs
Outputs of similar age from Frontiers in immunology
#18
of 442 outputs
Altmetric has tracked 25,806,763 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 32,415 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,009 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 442 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.