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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update
|
|---|---|
| Published in |
Frontiers in immunology, April 2017
|
| DOI | 10.3389/fimmu.2017.00405 |
| Pubmed ID | |
| Authors |
Hua Su, Chun-Tao Lei, Chun Zhang |
| Abstract |
Interleukin-6 (IL-6) is a pleiotropic cytokine that not only regulates the immune and inflammatory response but also affects hematopoiesis, metabolism, and organ development. IL-6 can simultaneously elicit distinct or even contradictory physiopathological processes, which is likely discriminated by the cascades of signaling pathway, termed classic and trans-signaling. Besides playing several important physiological roles, dysregulated IL-6 has been demonstrated to underlie a number of autoimmune and inflammatory diseases, metabolic abnormalities, and malignancies. This review provides an overview of basic concept of IL-6 signaling pathway as well as the interplay between IL-6 and renal-resident cells, including podocytes, mesangial cells, endothelial cells, and tubular epithelial cells. Additionally, we summarize the roles of IL-6 in several renal diseases, such as IgA nephropathy, lupus nephritis, diabetic nephropathy, acute kidney injury, and chronic kidney disease. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 29% |
| United States | 1 | 14% |
| Unknown | 4 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 456 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 456 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 73 | 16% |
| Student > Bachelor | 57 | 13% |
| Student > Master | 52 | 11% |
| Researcher | 34 | 7% |
| Student > Doctoral Student | 32 | 7% |
| Other | 60 | 13% |
| Unknown | 148 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 105 | 23% |
| Biochemistry, Genetics and Molecular Biology | 75 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 26 | 6% |
| Agricultural and Biological Sciences | 25 | 5% |
| Immunology and Microbiology | 19 | 4% |
| Other | 51 | 11% |
| Unknown | 155 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2024.
All research outputs
#2,530,442
of 25,782,229 outputs
Outputs from Frontiers in immunology
#2,548
of 32,380 outputs
Outputs of similar age
#44,971
of 324,319 outputs
Outputs of similar age from Frontiers in immunology
#43
of 415 outputs
Altmetric has tracked 25,782,229 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 32,380 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,319 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 415 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.