Title |
4,4′-Diaponeurosporene-Producing Bacillus subtilis Increased Mouse Resistance against Salmonella typhimurium Infection in a CD36-Dependent Manner
|
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Published in |
Frontiers in immunology, April 2017
|
DOI | 10.3389/fimmu.2017.00483 |
Pubmed ID | |
Authors |
Haofei Liu, Wenwen Xu, Qinghua Yu, Qian Yang |
Abstract |
Deficient mucosal innate immunity is a hallmark of infectious diarrhea, such as Salmonella typhimurium (S. typhimurium)-induced gastroenteritis. Here, we report that oral administration of a 4,4'-diaponeurosporene-producing Bacillus subtilis (B.s-Dia) could improve mice mucosal immunity, as showed by an increased resistance against S. typhimurium infection. Intragastric administration of B.s-Dia for 7 days could increase the secretion of CCL20 by intestinal epithelial cells (IECs) and then recruit more dendritic cells. Meanwhile, the number of CD8αα(+) intraepithelial lymphocytes, which play a critical role in downregulating immune responses, was also reduced, probably as a consequence of the decrease of IEC-derived TGFβ. Further study showed that CD36 played a critical role in B.s-Dia-induced immune enhancement, as blocking CD36 signal with a specific antagonist, sulfo-N-succinimidyl oleate, led to the inability of B.s-Dia to enhance mucosal innate immunity. |
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Netherlands | 1 | 50% |
United Kingdom | 1 | 50% |
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Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
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Unknown | 14 | 100% |
Demographic breakdown
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Student > Master | 3 | 21% |
Student > Ph. D. Student | 2 | 14% |
Professor | 1 | 7% |
Researcher | 1 | 7% |
Unspecified | 1 | 7% |
Other | 0 | 0% |
Unknown | 6 | 43% |
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Immunology and Microbiology | 2 | 14% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
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Unspecified | 1 | 7% |
Other | 1 | 7% |
Unknown | 6 | 43% |