Title |
The Innate Immune Cross Talk between NK Cells and Eosinophils Is Regulated by the Interaction of Natural Cytotoxicity Receptors with Eosinophil Surface Ligands
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Published in |
Frontiers in immunology, April 2017
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DOI | 10.3389/fimmu.2017.00510 |
Pubmed ID | |
Authors |
Silvia Pesce, Fredrik B. Thoren, Claudia Cantoni, Carola Prato, Lorenzo Moretta, Alessandro Moretta, Emanuela Marcenaro |
Abstract |
Previous studies suggested that the cross talk between NK cells and other cell types is crucial for the regulation of both innate and adaptive immune responses. In the present study, we analyzed the phenotypic and functional outcome of the interaction between resting or cytokine-activated NK cells and eosinophils derived from non-atopic donors. Our results provide the first evidence that a natural cytotoxicity receptor (NCR)/NCR ligand-dependent cross talk between NK cells and eosinophils may be important to upregulate the activation state and the effector function of cytokine-primed NK cells. This interaction also promotes the NK-mediated editing process of dendritic cells that influence the process of Th1 polarization. In turn, this cross talk also resulted in eosinophil activation and acquisition of the characteristic features of antigen-presenting cells. At higher NK/eosinophil ratios, cytokine-primed NK cells were found to kill eosinophils via NKp46 and NKp30, thus suggesting a potential immunoregulatory role for NK cells in dampening inflammatory responses involving eosinophils. |
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Geographical breakdown
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United Kingdom | 2 | 25% |
Netherlands | 1 | 13% |
United States | 1 | 13% |
Unknown | 4 | 50% |
Demographic breakdown
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Members of the public | 5 | 63% |
Scientists | 1 | 13% |
Science communicators (journalists, bloggers, editors) | 1 | 13% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
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Germany | 1 | 2% |
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Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 8 | 17% |
Student > Bachelor | 5 | 11% |
Student > Master | 4 | 9% |
Student > Postgraduate | 3 | 7% |
Other | 6 | 13% |
Unknown | 9 | 20% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 8 | 17% |
Biochemistry, Genetics and Molecular Biology | 7 | 15% |
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Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 2 | 4% |
Unknown | 11 | 24% |