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Ionizing Radiation-Induced Immune and Inflammatory Reactions in the Brain

Overview of attention for article published in Frontiers in immunology, May 2017
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Title
Ionizing Radiation-Induced Immune and Inflammatory Reactions in the Brain
Published in
Frontiers in immunology, May 2017
DOI 10.3389/fimmu.2017.00517
Pubmed ID
Authors

Katalin Lumniczky, Tünde Szatmári, Géza Sáfrány

Abstract

Radiation-induced late brain injury consisting of vascular abnormalities, demyelination, white matter necrosis, and cognitive impairment has been described in patients subjected to cranial radiotherapy for brain tumors. Accumulating evidence suggests that various degrees of cognitive deficit can develop after much lower doses of ionizing radiation, as well. The pathophysiological mechanisms underlying these alterations are not elucidated so far. A permanent deficit in neurogenesis, chronic microvascular alterations, and blood-brain barrier dysfunctionality are considered among the main causative factors. Chronic neuroinflammation and altered immune reactions in the brain, which are inherent complications of brain irradiation, have also been directly implicated in the development of cognitive decline after radiation. This review aims to give a comprehensive overview on radiation-induced immune alterations and inflammatory reactions in the brain and summarizes how these processes can influence cognitive performance. The available data on the risk of low-dose radiation exposure in the development of cognitive impairment and the underlying mechanisms are also discussed.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 184 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 184 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 42 23%
Researcher 27 15%
Student > Master 21 11%
Student > Bachelor 14 8%
Professor > Associate Professor 9 5%
Other 28 15%
Unknown 43 23%
Readers by discipline Count As %
Medicine and Dentistry 31 17%
Biochemistry, Genetics and Molecular Biology 22 12%
Neuroscience 22 12%
Agricultural and Biological Sciences 18 10%
Physics and Astronomy 8 4%
Other 30 16%
Unknown 53 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 October 2022.
All research outputs
#14,918,049
of 25,382,440 outputs
Outputs from Frontiers in immunology
#13,191
of 31,531 outputs
Outputs of similar age
#164,980
of 324,919 outputs
Outputs of similar age from Frontiers in immunology
#242
of 411 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,531 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,919 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 411 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.