Title |
Expanding Role of T Cells in Human Autoimmune Diseases of the Central Nervous System
|
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Published in |
Frontiers in immunology, June 2017
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DOI | 10.3389/fimmu.2017.00652 |
Pubmed ID | |
Authors |
Deepti Pilli, Alicia Zou, Fiona Tea, Russell C. Dale, Fabienne Brilot |
Abstract |
It is being increasingly recognized that a dysregulation of the immune system plays a vital role in neurological disorders and shapes the treatment of the disease. Aberrant T cell responses, in particular, are key in driving autoimmunity and have been traditionally associated with multiple sclerosis. Yet, it is evident that there are other neurological diseases in which autoreactive T cells have an active role in pathogenesis. In this review, we report on the recent progress in profiling and assessing the functionality of autoreactive T cells in central nervous system (CNS) autoimmune disorders that are currently postulated to be primarily T cell driven. We also explore the autoreactive T cell response in a recently emerging group of syndromes characterized by autoantibodies against neuronal cell-surface proteins. Common methodology implemented in T cell biology is further considered as it is an important determinant in their detection and characterization. An improved understanding of the contribution of autoreactive T cells expands our knowledge of the autoimmune response in CNS disorders and can offer novel methods of therapeutic intervention. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 4 | 18% |
United Kingdom | 3 | 14% |
Ireland | 1 | 5% |
Malaysia | 1 | 5% |
Australia | 1 | 5% |
Switzerland | 1 | 5% |
Mexico | 1 | 5% |
Unknown | 10 | 45% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 16 | 73% |
Scientists | 4 | 18% |
Practitioners (doctors, other healthcare professionals) | 2 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 112 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 29 | 26% |
Student > Master | 16 | 14% |
Researcher | 16 | 14% |
Student > Bachelor | 14 | 13% |
Student > Postgraduate | 4 | 4% |
Other | 11 | 10% |
Unknown | 22 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 17 | 15% |
Immunology and Microbiology | 16 | 14% |
Biochemistry, Genetics and Molecular Biology | 15 | 13% |
Medicine and Dentistry | 10 | 9% |
Neuroscience | 8 | 7% |
Other | 18 | 16% |
Unknown | 28 | 25% |