Title |
Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity
|
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Published in |
Frontiers in immunology, July 2017
|
DOI | 10.3389/fimmu.2017.00861 |
Pubmed ID | |
Authors |
Emmanuel C. Patin, Selinda Jane Orr, Ulrich E. Schaible |
Abstract |
The macrophage-inducible C-type lectin (Mincle) is an innate immune receptor on myeloid cells sensing diverse entities including pathogens and damaged cells. Mincle was first described as a receptor for the mycobacterial cell wall glycolipid, trehalose-6,6'-dimycolate, or cord factor, and the mammalian necrotic cell-derived alarmin histone deacetylase complex unit Sin3-associated protein 130. Upon engagement by its ligands, Mincle induces secretion of innate cytokines and other immune mediators modulating inflammation and immunity. Since its discovery more than 25 years ago, the understanding of Mincle's immune function has made significant advances in recent years. In addition to mediating immune responses to infectious agents, Mincle has been linked to promote tumor progression, autoimmunity, and sterile inflammation; however, further studies are required to completely unravel the complex role of Mincle in these distinct host responses. In this review, we discuss recent findings on Mincle's biology with an emphasis on its diverse functions in immunity. |
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Geographical breakdown
Country | Count | As % |
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Mexico | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 108 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 18 | 17% |
Student > Ph. D. Student | 17 | 16% |
Researcher | 14 | 13% |
Student > Master | 13 | 12% |
Student > Doctoral Student | 7 | 6% |
Other | 15 | 14% |
Unknown | 24 | 22% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 18 | 17% |
Biochemistry, Genetics and Molecular Biology | 16 | 15% |
Agricultural and Biological Sciences | 16 | 15% |
Medicine and Dentistry | 10 | 9% |
Chemistry | 9 | 8% |
Other | 13 | 12% |
Unknown | 26 | 24% |