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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Single-Domain Antibodies As Versatile Affinity Reagents for Analytical and Diagnostic Applications
|
|---|---|
| Published in |
Frontiers in immunology, August 2017
|
| DOI | 10.3389/fimmu.2017.00977 |
| Pubmed ID | |
| Authors |
Gualberto Gonzalez-Sapienza, Martín A. Rossotti, Sofía Tabares-da Rosa |
| Abstract |
With just three CDRs in their variable domains, the antigen-binding site of camelid heavy-chain-only antibodies (HcAbs) has a more limited structural diversity than that of conventional antibodies. Even so, this does not seem to limit their specificity and high affinity as HcAbs against a broad range of structurally diverse antigens have been reported. The recombinant form of their variable domain [nanobody (Nb)] has outstanding properties that make Nbs, not just an alternative option to conventional antibodies, but in many cases, these properties allow them to reach analytical or diagnostic performances that cannot be accomplished with conventional antibodies. These attributes include comprehensive representation of the immune specificity in display libraries, easy adaptation to high-throughput screening, exceptional stability, minimal size, and versatility as affinity building block. Here, we critically reviewed each of these properties and highlight their relevance with regard to recent developments in different fields of immunosensing applications. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Romania | 3 | 33% |
| United States | 1 | 11% |
| Switzerland | 1 | 11% |
| Mexico | 1 | 11% |
| Unknown | 3 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 67% |
| Scientists | 3 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 237 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 237 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 42 | 18% |
| Researcher | 38 | 16% |
| Student > Bachelor | 25 | 11% |
| Student > Master | 24 | 10% |
| Student > Doctoral Student | 12 | 5% |
| Other | 25 | 11% |
| Unknown | 71 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 72 | 30% |
| Agricultural and Biological Sciences | 30 | 13% |
| Immunology and Microbiology | 17 | 7% |
| Chemistry | 7 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
| Other | 24 | 10% |
| Unknown | 81 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2023.
All research outputs
#2,530,945
of 25,382,440 outputs
Outputs from Frontiers in immunology
#2,508
of 31,537 outputs
Outputs of similar age
#46,170
of 325,576 outputs
Outputs of similar age from Frontiers in immunology
#50
of 447 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,537 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 325,576 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 447 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.