Title |
Dual Face of Vγ9Vδ2-T Cells in Tumor Immunology: Anti- versus Pro-Tumoral Activities
|
---|---|
Published in |
Frontiers in immunology, August 2017
|
DOI | 10.3389/fimmu.2017.01041 |
Pubmed ID | |
Authors |
Zheng Xiang, Wenwei Tu |
Abstract |
Vγ9Vδ2-T cells are considered as potent effector cells for tumor immunotherapy through directly killing tumor cells and indirectly regulating other innate and adaptive immune cells to establish antitumoral immunity. The antitumoral activity of Vγ9Vδ2-T cells is governed by a complicated set of activating and inhibitory cell receptors. In addition, cytokine milieu in tumor microenvironment can also induce the pro-tumoral activities and functional plasticity of Vγ9Vδ2-T cells. Here, we review the anti- versus pro-tumoral activities of Vγ9Vδ2-T cells and discuss the mechanisms underlying the recognition, activation, differentiation and regulation of Vγ9Vδ2-T cells in tumor immunosurveillance. The comprehensive understanding of the dual face of Vγ9Vδ2-T cells in tumor immunology may improve the therapeutic efficacy and clinical outcomes of Vγ9Vδ2-T cell-based tumor immunotherapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 20% |
United Kingdom | 1 | 20% |
Switzerland | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 61 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 16 | 26% |
Researcher | 10 | 16% |
Student > Ph. D. Student | 5 | 8% |
Other | 4 | 7% |
Student > Bachelor | 2 | 3% |
Other | 3 | 5% |
Unknown | 21 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 17 | 28% |
Immunology and Microbiology | 6 | 10% |
Agricultural and Biological Sciences | 5 | 8% |
Medicine and Dentistry | 5 | 8% |
Nursing and Health Professions | 1 | 2% |
Other | 4 | 7% |
Unknown | 23 | 38% |