Title |
Modulation of Multiple Sclerosis and Its Animal Model Experimental Autoimmune Encephalomyelitis by Food and Gut Microbiota
|
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Published in |
Frontiers in immunology, September 2017
|
DOI | 10.3389/fimmu.2017.01081 |
Pubmed ID | |
Authors |
Ward J. van den Hoogen, Jon D. Laman, Bert A. ’t Hart |
Abstract |
Multiple sclerosis (MS) is an autoimmune neurological disease characterized by chronic inflammation of the central nervous system (CNS), leading to demyelination, axonal damage, and symptoms such as fatigue and disability. Although the cause of MS is not known, the infiltration of peripherally activated immune cells into the CNS has a key pathogenic role. Accumulating evidence supports an important role of diet and gut microbiota in immune-mediated diseases. Preclinical as well as clinical studies suggest a role for gut microbiota and dietary components in MS. Here, we review these recent studies on gut microbiota and dietary interventions in MS and its animal model experimental autoimmune encephalomyelitis. We also propose directions for future research. |
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Country | Count | As % |
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Canada | 4 | 14% |
United Kingdom | 3 | 11% |
Denmark | 1 | 4% |
Luxembourg | 1 | 4% |
Georgia | 1 | 4% |
South Africa | 1 | 4% |
Australia | 1 | 4% |
Spain | 1 | 4% |
Other | 1 | 4% |
Unknown | 10 | 36% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 22 | 79% |
Practitioners (doctors, other healthcare professionals) | 5 | 18% |
Scientists | 1 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 186 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 28 | 15% |
Student > Master | 25 | 13% |
Student > Bachelor | 21 | 11% |
Student > Ph. D. Student | 20 | 11% |
Student > Doctoral Student | 16 | 9% |
Other | 33 | 18% |
Unknown | 43 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 27 | 15% |
Biochemistry, Genetics and Molecular Biology | 21 | 11% |
Agricultural and Biological Sciences | 21 | 11% |
Medicine and Dentistry | 20 | 11% |
Neuroscience | 16 | 9% |
Other | 29 | 16% |
Unknown | 52 | 28% |