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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Antimicrobial Peptides As Biologic and Immunotherapeutic Agents against Cancer: A Comprehensive Overview
|
|---|---|
| Published in |
Frontiers in immunology, October 2017
|
| DOI | 10.3389/fimmu.2017.01320 |
| Pubmed ID | |
| Authors |
Raheleh Roudi, Nicholas L. Syn, Maryam Roudbary |
| Abstract |
Antimicrobial peptides (AMPs) are a pervasive and evolutionarily ancient component of innate host defense which is present in virtually all classes of life. In recent years, evidence has accumulated that parallel or de novo mechanisms by which AMPs curb infectious pathologies are also effective at restraining cancer cell proliferation and dissemination, and have consequently stimulated significant interest in their deployment as novel biologic and immunotherapeutic agents against human malignancies. In this review, we explicate the biochemical underpinnings of their tumor-selectivity, and discuss results of recent clinical trials (outside of oncologic indications) which substantiate their safety and tolerability profiles. Next, we present evidence for their preclinical antitumor activity, systematically organized by the major and minor classes of natural AMPs. Finally, we discuss the barriers to their clinical implementation and envision directions for further development. |
X Demographics
The data shown below were collected from the profiles of 20 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 5 | 25% |
| United States | 2 | 10% |
| Canada | 1 | 5% |
| Ecuador | 1 | 5% |
| Mexico | 1 | 5% |
| Switzerland | 1 | 5% |
| France | 1 | 5% |
| Unknown | 8 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 70% |
| Scientists | 3 | 15% |
| Practitioners (doctors, other healthcare professionals) | 2 | 10% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 148 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 18% |
| Student > Master | 22 | 15% |
| Researcher | 15 | 10% |
| Student > Bachelor | 13 | 9% |
| Other | 11 | 7% |
| Other | 20 | 14% |
| Unknown | 40 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 31 | 21% |
| Agricultural and Biological Sciences | 18 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 9% |
| Chemistry | 13 | 9% |
| Immunology and Microbiology | 8 | 5% |
| Other | 16 | 11% |
| Unknown | 48 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2018.
All research outputs
#3,815,943
of 25,461,852 outputs
Outputs from Frontiers in immunology
#4,321
of 31,696 outputs
Outputs of similar age
#67,621
of 335,954 outputs
Outputs of similar age from Frontiers in immunology
#91
of 544 outputs
Altmetric has tracked 25,461,852 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,696 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,954 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 544 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.