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The Gateway Reflex, a Novel Neuro-Immune Interaction for the Regulation of Regional Vessels

Overview of attention for article published in Frontiers in immunology, October 2017
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Title
The Gateway Reflex, a Novel Neuro-Immune Interaction for the Regulation of Regional Vessels
Published in
Frontiers in immunology, October 2017
DOI 10.3389/fimmu.2017.01321
Pubmed ID
Authors

Yuki Tanaka, Yasunobu Arima, Daisuke Kamimura, Masaaki Murakami

Abstract

The gateway reflex is a new phenomenon that explains how immune cells bypass the blood-brain barrier to infiltrate the central nervous system (CNS) and trigger neuroinflammation. To date, four examples of gateway reflexes have been discovered, each described by the stimulus that evokes the reflex. Gravity, electricity, pain, and stress have all been found to create gateways at specific regions of the CNS. The gateway reflex, the most recently discovered of the four, has also been shown to upset the homeostasis of organs in the periphery through its action on the CNS. These reflexes provide novel therapeutic targets for the control of local neuroinflammation and organ function. Each gateway reflex is activated by different neural activations and induces inflmammation at different regions in the CNS. Therefore, it is theoretically possible to manipulate each independently, providing a novel therapeutic strategy to control local neuroinflammation and peripheral organ homeostasis.

X Demographics

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The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 47 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 21%
Student > Ph. D. Student 8 17%
Other 6 13%
Professor > Associate Professor 3 6%
Student > Doctoral Student 2 4%
Other 5 11%
Unknown 13 28%
Readers by discipline Count As %
Medicine and Dentistry 15 32%
Neuroscience 6 13%
Agricultural and Biological Sciences 3 6%
Immunology and Microbiology 3 6%
Biochemistry, Genetics and Molecular Biology 2 4%
Other 3 6%
Unknown 15 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2017.
All research outputs
#14,787,133
of 25,382,440 outputs
Outputs from Frontiers in immunology
#12,926
of 31,537 outputs
Outputs of similar age
#168,125
of 336,554 outputs
Outputs of similar age from Frontiers in immunology
#291
of 565 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,537 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 336,554 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 565 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.